Therapeutic implications of germline genetic findings in cancer

Therapeutic implications of germline genetic findings in cancerTherapeutic implications of germline genetic findings in cancer, Published online: 19 February 2019; doi:10.1038/s41571-019-0179-3The majority of genetically targeted approaches to cancer therapy focus on somatic mutations. However, evidence is accumulating in support of a role for germline genetic alterations in determining responsiveness to treatment. In this Review, the authors summarize the therapeutic potential of knowledge of the germline genome in patients with cancer.

Source: Nature Reviews Clinical Oncology - February 19, 2019 Category: Cancer & Oncology Authors: Subotheni Thavaneswaran Emma Rath Kathy Tucker Anthony M. Joshua Dominique Hess Mark Pinese Mandy L. Ballinger David M. Thomas Source Type: research