NO donors induce vascular relaxation by different cellular mechanisms in hypertensive and normotensive rats

ConclusionOur results indicate that SNP and RuBPY-induced mesenteric resistance artery relaxation involves NO/sGC/cGMP/PKG pathway activation. K+ channels and SERCA activation is required to SNP but not for RuBPY-induced relaxation. Moreover, SERCA seems to be impaired in hypertensive 2K-1C rat mesenteric resistance arteries although it does not impact SNP- or RuBPY-induced relaxation.Graphical abstract

Source: Nitric Oxide - February 15, 2019 Category: Chemistry Source Type: research