A microfluidic flow-focusing device for low sample consumption serial synchrotron crystallography experiments in liquid flow
This article presents a fast and optimized manufacturing route to metal – polyimide microfluidic flow-focusing devices which allow for the collection of X-ray diffraction data in flow. The flow-focusing conditions allow for sample consumption to be significantly decreased, while also opening up the possibility of more complex experiments such as rapid mixing for time-resolved serial crystallography. This high-repetition-rate experiment allows for full datasets to be obtained quickly ( ∼ 1 h) from crystal slurries in liquid flow. The X-ray compatible microfluidic chips are easily manufacturable, reliable and durable and require sample-flow rates on the order of only 30 µ l h − 1.
Source: Journal of Synchrotron Radiation - Category: Physics Authors: Monteiro, D.C.F. Vakili, M. Harich, J. Sztucki, M. Meier, S.M. Horrell, S. Josts, I. Trebbin, M. Tags: serial synchrotron crystallography microfluidics flow focusing research papers Source Type: research
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