New Hepatitis Meds, Such as Harvoni and Sovaldi, Are Saving Lives: Study

TUESDAY, Feb. 12, 2019 -- New (and pricey) hepatitis C medicines, such as Harvoni and Sovaldi, are living up to their promise and greatly reducing patients'odds for liver cancer and death, a new French study finds. The news came as little surprise...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news

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Hepatitis C virus nonstructural 5A protein inhibits the starvation‑induced apoptosis of hepatoblastoma cells by increasing Beclin 1 expression. Oncol Rep. 2019 Mar 13;: Authors: Quan M, Liu S, Zhou L, Feng S, Zhang Y, Cheng J Abstract Hepatitis C virus (HCV) nonstructural protein 5A (NS5A) modulates cellular apoptosis, which is involved in the occurrence and development of liver cancer. The mechanisms of apoptosis inhibition by NS5A in liver cancer cells remains unclear. Beclin 1, which functions upstream of autophagosome formation, is upregulated by NS5A. Autophagy, an evolutionarily ...
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
In this study, we have performed a genetic expression analysis comparing mRNA expression by NK cells from HCC patients to patients with the pre-neoplastic condition of liver cirrhosis and to healthy donors. The bioinformatic analysis has been completed by an immunophenotypic study and functional analysis of the main NK cell functions. It is known that NK cells may present functional defects in HCC patients however previous studies have not systematically address the molecular mechanisms associated with these defects by an unbiased genetic expression study. We could identify altered cellular pathways and hypothesize possibl...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
This study aimed to prospectively invest igate HCC recurrence and its predictors after curative treatment for HCC.MethodsA total of 3012 patients with chronic HCV infection, with or without cirrhosis, who were treated with DAAs were enrolled between January 1, 2015 and January 31, 2017 as per the institutional review board approved study protocol at 15 institutions, including 10 university hospitals and five high ‐volume centers in the Kyusyu area of Japan. Of the 3012 patients, 459 patients who had HCC but were cured with surgery or ablation therapy (curative treatment) before the use of DAAs were included in the analys...
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research
To the Editor The multicenter study by Xu et al concluding that recurrence after hepatocellular carcinoma (HCC) resection is associated with sex deserves robust comment. The sophisticated multivariate Cox regression analyses failed to account for smoking status (dose and duration and also cessation after resection) despite smoking being an independent and a dose-related contributing factor for HCC all over the world, including Asia. The mean relative risk was 1.5 but exposure was high, specifically in China, where the prevalence of smoking was almost 50% in men, 22-fold that of women. In a large European cohort, the popula...
Source: JAMA Surgery - Category: Sports Medicine Source Type: research
By HANS DUVEFELT MD Jeanette Brown had lost twenty pounds, and she was worried. “I’m not trying,” she told me at her regular diabetes visit as I pored over her lab results. What I saw sent a chill down my spine: A normal weight, diet controlled diabetic for many years, her glycosylated hemoglobin had jumped from 6.9 to 9.3 in three months while losing that much weight. That is exactly what happened to my mother some years ago, before she was diagnosed with the pancreatic cancer that took her life in less than two years. Jeanette had a normal physical exam and all her bloodwork except for t...
Source: The Health Care Blog - Category: Consumer Health News Authors: Tags: Health Policy Medicare Hans Duvefelt Managed Care Source Type: blogs
Liver cancer (hepatocellular carcinoma [HCC]) incidence and mortality rates have been increasing in most countries for several decades. Currently, HCC is the second most common cause of cancer-related death in the world and represents the fastest rising cause of cancer-related deaths in the United States. Chronic hepatitis B virus (HBV) and hepatitis C virus are the primary underlying causes of HCC, with contributions from alcohol, tobacco, aflatoxin, obesity, and metabolic syndrome. In patients with chronic hepatitis C virus, the risk of HCC can be reduced rapidly with short-term, direct-acting antiviral medications. In c...
Source: JAMA Internal Medicine - Category: Internal Medicine Source Type: research
Liu et al. collected detailed information on liver cancer aetiology between 1990 –2016, derived from the global burden of disease in 2016. In this issue of the Journal, they show that liver cancer remains a major public health concern globally, though control of hepatitis B virus and hepatitis C virus infections has contributed to the decrease in liver cancer incidence in some regions. They report an unfavourable trend in countries with high socio-demographic index, including the Netherlands, the UK, and the USA.
Source: Journal of Hepatology - Category: Gastroenterology Authors: Tags: Editorial Desk Source Type: research
CONCLUSION: After establishing HCV replication, the lack of global changes in cellular gene expression indicates an adaptation to chronic infection, while the downregulation of mitochondrial respiratory chain genes indicates how a virus may further contribute to cancer cell-like metabolic reprogramming ("Warburg effect") even in the hepatocellular carcinoma cells used here. PMID: 30875926 [PubMed - in process]
Source: Molecular Medicine - Category: Molecular Biology Authors: Tags: Int J Mol Sci Source Type: research
AbstractChronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infection are the most important underlying causes for the development of hepatocellular carcinoma (HCC) worldwide. Determining the optimal approach for management of the viral infection and the HCC depends on the virus and the stage of the cancer. In patients with HCV-associated HCC, there are multiple reasons to first treat the HCC. Firstly, in case of a curable HCC, the urgency for HCC treatment is important to avoid progression during HCV treatment. Secondly, the presence of HCC itself appears to reduce the rates of sustained virological response (SVR)...
Source: Digestive Diseases and Sciences - Category: Gastroenterology Source Type: research
This study provides evidence that the HCV core protein is a pro-metastatic protein that can interact directly with and modulate the functions of cellular metastasis suppressor Nm23-H1.
Source: Archives of Virology - Category: Virology Source Type: research
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