Surviving dengue fever may protect some people against Zika, study suggests 

People in Pau de Lima, a Brazilian city hit hard by the 2015 Zika outbreak, who had had dengue fever had more dengue antibodies and were less likely to catch Zika, Yale researchers found.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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We described ZIKV and DENV serological markers and the maternal-fetal t ransfer of antibodies among mothers and neonates after the ZIKV microcephaly outbreak in Northeast Brazil (2016). We included 89 microcephaly cases and 173 neonate controls at time of birth and their mothers. Microcephaly cases were defined as newborns with a particular head circumference (2 SD belo w the mean). Two controls without microcephaly were matched by the expected date of delivery and area of residence. We tested maternal serum for recent (ZIKV genome, IgM and IgG3 anti-NS1) and previous (ZIKV and DENV neutralizing antibodies [NAbs]) markers ...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
Analysis of community where 73% of residents contracted Zika in 2015 offers new clues about epidemicScientists studying the 2015 Zika outbreak in Brazil have discovered that people previously exposed to dengue may have been protected from the virus.Three-quarters of the inhabitants of a favela in the country ’s north-east caught the mosquito-borne Zika virus during the epidemic.The outbreak left more than 3,000 babies across Brazil with microcephaly, a birth defect caused by mothers catching the virus during pregnancy.Continue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Global health Zika virus Global development Brazil Infectious diseases Science Americas World news Source Type: news
While 73% of Salvador, Brazil residents were infected during a 2015 Zika outbreak, those with dengue antibodies were less likely to be affected.
Source: Yale Science and Health News - Category: Universities & Medical Training Source Type: news
(University of Pittsburgh) The higher a person's immunity to dengue virus, the lower their risk of Zika infection, an international team of scientists report today. The study -- which followed nearly 1,500 people living in a poor neighborhood at the heart of the 2015 Zika outbreak in Brazil -- also provides evidence for why Brazil's Zika epidemic has largely petered out.
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news
The clinical outcomes associated with Zika virus (ZIKV) in the Americas have been well documented, but other aspects of the pandemic, such as attack rates and risk factors, are poorly understood. We prospectively followed a cohort of 1453 urban residents in Salvador, Brazil, and, using an assay that measured immunoglobulin G3 (IgG3) responses against ZIKV NS1 antigen, we estimated that 73% of individuals were infected during the 2015 outbreak. Attack rates were spatially heterogeneous, varying by a factor of 3 within a community spanning 0.17 square kilometers. Preexisting high antibody titers to dengue virus were associat...
Source: ScienceNOW - Category: Science Authors: Tags: Ecology, Epidemiology r-articles Source Type: news
by Caroline S. de Freitas, Luiza M. Higa, Carolina Q. Sacramento, Andr é C. Ferreira, Patrícia A. Reis, Rodrigo Delvecchio, Fabio L. Monteiro, Giselle Barbosa-Lima, Harrison James Westgarth, Yasmine Rangel Vieira, Mayara Mattos, Natasha Rocha, Lucas Villas Bôas Hoelz, Rennan Papaleo Paes Leme, Mônica M. Bastos, Gisele Olinto L. Rodrigues, Carla Elizabeth M. Lopes, Celso Martins Queiroz-Junior, Cristiano X. Lima, Vivian V. Costa, Mauro M. Teixeira, Fernando A. Bozza, Patrícia T. Bozza, Nubia Boechat, Amilcar Tanuri, Thiago Moreno L. Souza Yellow fever virus (YFV) is a member of theFlaviviri...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
We reported previously that enzyme-linked immunosorbent assays (ELISAs) based on the nonstructural protein 1 (NS1) of DENV serotype 1 (DENV1) and ZIKV can distinguish primary DENV1, secondary DENV, and ZIKV infections. Whether ELISAs based on NS1 proteins of other DENV serotypes can discriminate various DENV and ZIKV infections remains unknown. We herein developed DENV2, DENV3, and DENV4 NS1 IgG ELISAs to test convalescent- and postconvalescent-phase samples from reverse transcription-PCR-confirmed cases, including 25 primary DENV1, 24 primary DENV2, 10 primary DENV3, 67 secondary DENV, 36 primary West Nile virus, 38 prima...
Source: Journal of Clinical Microbiology - Category: Microbiology Authors: Tags: Virology Source Type: research
by Chantal B. F. Vogels, Claudia R ückert, Sean M. Cavany, T. Alex Perkins, Gregory D. Ebel, Nathan D. Grubaugh Epidemiological synergy between outbreaks of viruses transmitted byAedes aegypti mosquitoes, such as chikungunya, dengue, and Zika viruses, has resulted in coinfection of humans with multiple viruses. Despite the potential impact on public health, we know only little about the occurrence and consequences of such coinfections. Here, we review the impact of coinfection on clinical disease in humans, discuss the possibility for co-transmission from mosquito to human, and describe a role for modeling transmissi...
Source: PLoS Biology: Archived Table of Contents - Category: Biology Authors: Source Type: research
(CNN) — From climate change to superbugs, the World Health Organization has laid out 10 big threats to our global health in 2019. And unless these threats get addressed, millions of lives will be in jeopardy. Here’s a snapshot of 10 urgent health issues, according to the United Nations’ public health agency: Not vaccinating when you can One of the most controversial recent health topics in the US is now an international concern. “Vaccine hesitancy — the reluctance or refusal to vaccinate despite the availability of vaccines — threatens to reverse progress made in tackling vaccine-prevent...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Health News CNN Local TV Source Type: news
Conclusion: This safe and easy to use multiplex assay allows the discrimination of alphavirus-specific reactivity within a single assay and has potential for epidemiological surveillance. It might also be useful for the development of a pan-alphavirus vaccine.
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
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