The motility regulator flhDC drives intracellular accumulation and tumor colonization of Salmonella

ConclusionsThis study demonstrates a mechanistic link between motility, intracellular accumulation and tumor colonization. Based on our results, we envision that therapeutic strains ofSalmonella could use inducibleflhDC to drive tumor colonization. More intratumoral bacteria would enable delivery of higher therapeutic payloads into tumors and would improve treatment efficacy.

http://link.springer.com/10.1186/s40425-018-0490-z

Source: Journal for Immunotherapy of Cancer - February 12, 2019 Category: Cancer & Oncology Source Type: research