SHINE: No Improvement With Intense IV Glucose Control in Stroke SHINE: No Improvement With Intense IV Glucose Control in Stroke

Intense intravenous glucose control does not better improve functional outcomes after an ischemic stroke than standard subcutaneous insulin therapy — and may increase risk for hypoglycemia.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Neurology & Neurosurgery News Source Type: news

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Authors: Zhu H, Chandra A, Geng X, Cheng Z, Tong Y, Du H, Ding Y Abstract BACKGROUND: Acute ischemic stroke (AIS) is associated with significant morbidity and mortality and has a very narrow window of treatment with fibrinolytics. We investigated the safety and efficacy of combined chlorpromazine and promethazine (C+P) treatment in AIS. METHODS: A total of 64 consecutive patients diagnosed with AIS were selected and were randomly (double-blind) assigned into either the control group (standard of care [SOC] treatment) or the treatment group (SOC+C+P [12.5+12.5 mg BID or 25+25 mg BID]) which were treated for 2 we...
Source: Journal of Neurosurgical Sciences - Category: Neurosurgery Tags: J Neurosurg Sci Source Type: research
Publication date: Available online 18 May 2019Source: Journal of Pharmacological SciencesAuthor(s): Ying Tang, Ming-Yue Li, Xin Zhang, Xing Jin, Jing Liu, Ping-He WeiAbstractStroke is one of the leading causes of long-term disabilities worldwide. Although exposure to an enriched environment (EE) initiated in the acute phase after stroke has neuroprotective effects and improves stroke outcome, it remains unclear whether EE has positive effects when started in a delayed time frame. Here we show that exposure to EE in the delayed phase notably ameliorates the ischemia-induced impairments in neurological functions and spatial ...
Source: Journal of Pharmacological Sciences - Category: Drugs & Pharmacology Source Type: research
ConclusionsIn patients with ACS, ticagrelor is more efficacious in protecting against new ischemic events and mortality than clopidogrel irrespective of the presence of HF. There is no difference between ticagrelor or clopidogrel treatment in new-onset HF post-ACS.
Source: American Heart Journal - Category: Cardiology Source Type: research
Publication date: Available online 17 May 2019Source: Journal of Psychiatric ResearchAuthor(s): Huai-bin Liang, Ji-rong He, Xuan-qiang Tu, Kai-qi Ding, Guo-Yuan Yang, Yu Zhang, Li-li ZengAbstractWe aimed to explore the circulating microRNAs biomarkers in the acute stage following cerebral ischemia to earlier warn late-onset post-stroke depression (PSD). A total of 251 consecutive patients with acute ischemic stroke were recruited. They were divided into three groups depending on whether PSD had occurred at 2 weeks or 3 months since stroke: early-onset PSD, late-onset PSD, and non-depressed group. Microarray assay was condu...
Source: Journal of Psychiatric Research - Category: Psychiatry Source Type: research
Abstract Cerebral ischemia can occur at any stage in life, but clinical consequences greatly differ depending on the developmental stage of the affected brain structures. Timing of the lesion occurrence seems to be critical, as it strongly interferes with neuronal circuit development and determines the way spontaneous plasticity takes place. Translational stroke research requires the use of animal models as they represent a reliable tool to understand the pathogenic mechanisms underlying the generation, progression, and pathological consequences of a stroke. Moreover, in vivo experiments are instrumental to invest...
Source: Neural Plasticity - Category: Neurology Authors: Tags: Neural Plast Source Type: research
CONCLUSION: HTPR was significantly associated with adverse ischemic outcomes at 1 year after PCI in Japanese patients receiving maintenance DAPT, indicating its potential as a prognostic indicator of clinical outcomes in this high-risk patient population. PMID: 31092743 [PubMed - as supplied by publisher]
Source: Journal of Atherosclerosis and Thrombosis - Category: Cardiology Tags: J Atheroscler Thromb Source Type: research
We are interested to read the study led by Park and associates1 about the risk of stroke in patients with nonarteritic anterior ischemic optic neuropathy (NAION). According to this retrospective cohort study, 1125 NAION patients were identified from January 1, 2004 to December 31, 2013, based on the Korean National Health Insurance Service (NHIS) –National Sample Cohort (NSC) database. The occurrence of incident NAION was associated with an increased risk of subsequent stroke in model 1 (crude analysis; hazard ratio [HR] = 1.31; 95% confidence interval [CI], 0.89–1.92), model 2 (adjusted analysis for demog...
Source: American Journal of Ophthalmology - Category: Opthalmology Authors: Tags: Correspondence Source Type: research
In conclusion, the evidence thus far has not been significant enough for the American College of Cardiology to recommend the incorporation of oral anticoagulants in the management of stable ischemic heart disease patients, in contrast to aspirin and clopidogrel. As the antithrombotic and antiischemic properties of these newer agents seem evident, so does their potential for increase in risk of bleeding events. Doctors have to individually tailor antithrombotic medication decisions based on the patient ’s risk-benefit profile.
Source: Current Cardiology Reports - Category: Cardiology Source Type: research
CONCLUSIONS: Thrombectomy appears to be a safe and effective method for the treatment of acute M2 segment occlusions of the MCA. Most of the cases had a dominant M2 branch, and all of them were occluded. Larger studies are needed to verify the benefits of thrombectomy for different settings of M2 occlusions. PMID: 31088246 [PubMed - as supplied by publisher]
Source: Interventional Neuroradiology - Category: Radiology Tags: Interv Neuroradiol Source Type: research
CONCLUSION: The present meta-analysis indicates that aircraft noise increases the risk of stroke, even if the overall finding just fails to reach statistical significance. The differing measures of exposure in the included studies, the lack of differentiation be- tween ischemic and hemorrhagic stroke, and the lack of consideration of maximum noise levels are all factors that may have led to a marked underestimation of the risk of stroke. PMID: 31092311 [PubMed - in process]
Source: Deutsches Arzteblatt International - Category: General Medicine Tags: Dtsch Arztebl Int Source Type: research
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