The chemical constituents of Penianthus longifolius Miers

Publication date: April 2019Source: Phytochemistry Letters, Volume 30Author(s): Georges Bellier Tabekoueng, Carine Mvot Akak, Moses K. Langat, Anatole Guy Blaise Azebaze, Alain Francois Kamdem Waffo, Dulcie A. Mulholland, Juliette Catherine VardamidesAbstractFourteen compounds were isolated from the roots, leaves and twigs of Penianthus longifolius Miers (Menispermaceae), including two previously unreported neo-clerodane diterpenoids, penianthin (1), its C-8 epimer (2). In addition, the previously reported O-methylmoschatoline (3), taraxerol (4), taraxerone (5), rubrosterone, (6), panuosterone (7), 22-epi-20-hydroxyecdysone (8), ergosterol peroxide (9), stigmast-5-ene-3,7-dione (10), stigmasterol (11), β-sitosterol (12), stigmasterol glucoside (13) and β-sitosterol glucoside (14) were isolated. The structures of the compounds were determined by means of NMR spectroscopic and mass spectrometric analysis. The absolute configurations of 1 and 2 were determined by circular dichroism analysis. Compounds 1 and 2 were screened against the NCI60 cancer cell panel but showed no significant activity at 10 μM.Graphical abstract
Source: Phytochemistry Letters - Category: Chemistry Source Type: research