Featured Review: Oral H1 antihistamines as ‘add-on’ therapy to topical treatment for eczema

The findings of this Cochrane Review may challenge the prescribing of H1 antihistamines for patients with eczema.This Cochrane Review assessed theeffects of oral H1 antihistamines as'add-on'therapy to topical treatment in adults and children with eczema. Are H1 antihistamines taken as tablets or liquid, effective and safe in people of any age with diagnosed eczema, if given in addition to creams and ointments, compared to treatment with an inactive substance (placebo) or nothing added to creams and ointments?Eczema (also known as'atopic eczema/dermatitis') is a skin disorder frequently affecting both children and adults. In developed countries, 10% to 20% of all people are affected by eczema during their lifetime. The main symptom is itch, which results in scratching and, together with skin inflammation, frequently produces reddening of the skin. The symptoms of eczema can lead to sleeplessness and fatigue, lowering quality of life. Antihistamines are frequently given for itch (specifically H1 antihistamines taken by mouth), and they may alleviate the symptoms of eczema when given in addition to conventional treatments directly applied to the skin (e.g. emollients, moisturisers, steroid creams), although they are not thought to cure it.Many antihistamines are available without prescription, for instance, cetirizine or loratadine. Although H1 antihistamines are frequently prescribed for treating eczema, we do not know whether they are effective and safe. The review includes 25...
Source: Cochrane News and Events - Category: Information Technology Authors: Source Type: news

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Publication date: January 2020Source: Learning and Individual Differences, Volume 77Author(s): Anke Heyder, Anna Südkamp, Ricarda SteinmayrAbstractAlthough positive teacher attitudes toward inclusion are often claimed as a prerequisite for successful inclusive education, quantitative empirical evidence for that claim is very scarce. This multilevel study explored the relations between teachers' attitudes toward inclusion and students' social integration and school well-being as indicators of successful inclusive education in 757 German primary school students and 37 teachers. Students with and without special educatio...
Source: Learning and Individual Differences - Category: Psychiatry & Psychology Source Type: research
Purpose: To quantify corneal backscattering by densitometry analysis after pre-Descemet endothelial keratoplasty (PDEK). Design: This is a prospective observational case series. Methods: Setting: Tertiary care hospital. Participants: Postoperative PDEK eyes with best-corrected visual acuity (BCVA) ≥20/40 without comorbidity. Observation procedure: Slit-lamp examination, Scheimpflug imaging (Pentacam; Oculus, Wetzlar, Germany), endothelial cell density (cells/mm2), and central corneal thickness (Visante; Carl Zeiss AG, Oberkochen, Germany) were performed. Corneal densitometry values for the entire depth of the co...
Source: Cornea - Category: Opthalmology Tags: Clinical Science Source Type: research
ConclusionThis study allowed us, by removing the entire septum as a whole structure, to redefine the concept of the septum as a complex structure based on islands of muscle fibers irregularly arranged in vertex, in a context of collagen tissue, similar to the structure of myomas. It appears to deeply involve the anterior and posterior uterine wall, resembling a “reverse letter H”.
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
Conclusions Our findings can contribute to the development of breast cancer survivorship care plans by emphasizing posttreatment SM. Implications for Practice Future SM support intervention for BCSs after treatment should focus on training SM skills, enhancing the survivor-provider relationship, and building survivor self-confidence.
Source: Cancer Nursing - Category: Nursing Tags: ARTICLES Source Type: research
Authors: Yeolekar ME Abstract Human lifespan has seen a rise globally. Extended lifespan is a trend projected to persist and continue. The gap is wide: from 52.67 years in the Central African Republic to 80.3 years in the OECD (Canada, Germany, Mexico, France, Japan, UK). In India the expectancy was 68.8 years in 2018. Concordant with the enhanced life span have been studies that explain determinants and mechanisms of human longevity, much of which has been attributed to better public health measures and improved care. The natural twin consequences of longevity: a) Frailty its characteristics and management and b) ...
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
CONCLUSIONS: Based on the main comparisons, we did not find consistent evidence that H1 AH treatments are effective as 'add-on' therapy for eczema when compared to placebo; evidence for this comparison was of low and moderate quality. However, fexofenadine probably leads to a small improvement in patient-assessed pruritus, with probably no significant difference in the amount of treatment used to prevent eczema flares. Cetirizine was no better than placebo in terms of physician-assessed clinical signs nor patient-assessed symptoms, and we found no evidence that loratadine was more beneficial than placebo, although all inte...
Source: Cochrane Database of Systematic Reviews - Category: General Medicine Authors: Tags: Cochrane Database Syst Rev Source Type: research
CONCLUSIONS: For the following research, the authors suggest SCORAD (Total) as primary outcome and SCORAD (objective), VAS (Itch), VAS (insomnia), EASI, POEM, and DLQI as secondary outcomes. Thirty six participants should be conducted a 4-week acupuncture period (twice weekly) and a 4-week follow-up. It is necessary to compare the differences of general symptoms according to presence of epigastric tenderness or dyspepsia at the screening level. PMID: 30477869 [PubMed - in process]
Source: Complementary Therapies in Medicine - Category: Complementary Medicine Authors: Tags: Complement Ther Med Source Type: research
ConclusionsSelf-reported adult-onset AD is common and has distinct phenotypes with lesional predilection for the hands and/or head/neck.
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
urham S, Boyle RJ Abstract BACKGROUND: Specific allergen immunotherapy (SIT) is a treatment that may improve disease severity in people with atopic eczema (AE) by inducing immune tolerance to the relevant allergen. A high quality systematic review has not previously assessed the efficacy and safety of this treatment. OBJECTIVES: To assess the effects of specific allergen immunotherapy (SIT), including subcutaneous, sublingual, intradermal, and oral routes, compared with placebo or a standard treatment in people with atopic eczema. SEARCH METHODS: We searched the following databases up to July 2015: the C...
Source: Cochrane Database of Systematic Reviews - Category: Journals (General) Authors: Tags: Cochrane Database Syst Rev Source Type: research
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