Whole genome sequencing-based analysis of tuberculosis (TB) in migrants: rapid tools for cross-border surveillance and to distinguish between recent transmission in the host country and new importations.
ConclusionWe provide a new model for optimising the analysis of cross-border surveillance of TB transmission in the scenario of global migration. PMID: 30696526 [PubMed - in process]
[The Conversation Africa] Important gains have been made in the global fight against tuberculosis (TB). Each year, fewer people are being diagnosed with the disease. The recent World Health Organisation (WHO) global TB report, which gathers data from 202 countries and territories, shows a 6.3% reduction in the number of new TB infections between 2015 and 2018. This trend of decreasing incidence is also evident in Africa, where it fell from 275 per 100 000 people in 2015 to 231 per 100 000 in 2018.
Conclusions: The spatial clusters of TB incidence shifted to the rural region and the fringe of the new urban area of Nanchang. Targeted management strategies for urban migrants in the process of urbanization should be strengthened.
BCG stimulation promotes dendritic cell proliferation and expression of VDR and CYP27B1 in vitamin D‑deficient mice. Mol Med Rep. 2019 Oct 30;: Authors: Yang H, Zhang H, Li Y, Xiang L, Liu J Abstract Vitamin D deficiency may lead to an increased risk of tuberculosis. In the present study, the effects of Mycobacterium tuberculosis (Mtb) infection on dendritic cells (DCs) derived from vitamin D‑deficient mice or normal control mice were investigated. A vitamin D‑deficient mouse model was established, and bone marrow‑derived DCs (BMDCs) were isolated and treated with GM‑CSF and in...
ConclusionsThis study shows that the alveolar microbiota profile in BAL samples from TB and IP patients, representing infectious and non-infectious lung diseases, respectively, is characterized by decreased diversity.
Publication date: Available online 8 November 2019Source: Respiratory InvestigationAuthor(s): Lucia Vietri, Annalisa Fui, Laura Bergantini, Miriana d’Alessandro, Paolo Cameli, Piersante Sestini, Paola Rottoli, Elena BargagliAbstractSerum amyloid A is an acute-phase protein with multiple immunological functions. Serum amyloid A is involved in lipid metabolism, inflammatory reactions, granuloma formation, and cancerogenesis. Additionally, serum amyloid A is involved in the pathogenesis of different autoimmune lung diseases. The levels of serum amyloid A has been evaluated in biological fluids of patients with different...
Publication date: Available online 9 November 2019Source: Respiratory Medicine Case ReportsAuthor(s): Wajahat Dawood, De La Garza Henriette, Gloria Iliescu, Cesar Moran, Horiana Grosu
A 24-year-old male presented to the emergency department with a purpuric rash that started a week prior on the arms, trunk, and legs, along with acute onset testicular pain radiating to the lower abdomen. Ultrasound performed during that ED visit showed bilateral testicular solid masses, hypovascular or avascular, a nd a hypervascular left testicle and epididymis (Figure 1). Differential based on ultrasound findings included: testicular carcinoma, granulomatous epididymoorchitis such as sarcoidosis or tuberculosis, adrenal rests, lymphoma, or metastases.
PMID: 31701705 [PubMed - in process]
Abstract BACKGROUND: Delays in isolating patients admitted to hospital with active pulmonary tuberculosis (PTB) can contribute to nosocomial transmission; however, in Korea, patients with clinically diagnosed PTB are not routinely isolated while awaiting microbiological confirmation of the diagnosis. We aimed to assess the extent of delays in isolating patients admitted with PTB and to identify the factors associated with delayed isolation. METHODS: We retrospectively reviewed the electronic medical records of patients aged ≥ 18 years with active PTB, between January 2008 and December 2017, from two Korean...