IL-10 is associated with increased mu-opioid receptor levels in major depressive disorder.

CONCLUSION: The results show that MOR levels may function as a possible component of the CIRS whilst there is no evidence that β-EP and EM-2 may modify the IRS. The significant correlation between MOR levels and IL-10 may be explained through central activation of the HPA-axis and increased B-cell numbers expressing MOR as a response to cytokine over-secretion in MDD.
PMID: 30677547 [PubMed - as supplied by publisher]

Source: Journal of the Association of European Psychiatrists - January 25, 2019 Category: Psychiatry Tags: Eur Psychiatry Source Type: research