Chronic Itch Management: Therapies Beyond Those Targeting the Immune System

Itch, a sensation that leads to a desire to scratch, becomes chronic when it persists for more than 6 weeks.1 Chronic itch can be debilitating and lead to a significantly reduced quality of life. It affects sleep, mood, and can cause symptoms of anxiety and depression.2 Pruritus may be perpetuated by inflammatory conditions, as seen in atopic dermatitis and psoriasis. However, chronic pruritus may not always have an inflammatory component, and therefore requires treatments that do not work on the immune system, but instead target the nerves.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Review Source Type: research

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CONCLUSION: A machine learning-based approach could provide better SI prediction performance compared to a conventional LR-based model. These may help primary care physicians to identify patients at risk of SI and will facilitate the early prevention of suicide. PMID: 32213803 [PubMed - as supplied by publisher]
Source: Psychiatry Investigation - Category: Psychiatry Tags: Psychiatry Investig Source Type: research
CONCLUSION: Patients with NSSI and/or suicide attempts were more likely to be female, younger, and showed higher levels of psychological disturbances. These findings highlight the importance of early detection and intervention for patients with NSSI. PMID: 32213802 [PubMed - as supplied by publisher]
Source: Psychiatry Investigation - Category: Psychiatry Tags: Psychiatry Investig Source Type: research
Authors: Kim SY, Jeon SW, Lim WJ, Oh KS, Shin DW, Cho SJ, Park JH, Shin YC Abstract OBJECTIVE: The aim of study is to investigate the relationship between serum vitamin D, c-reactive protein (CRP) levels, and anxiety symptoms. METHODS: Serum vitamin D and CRP levels of 51,003 Korean adult participants were collected retrospectively. Anxiety symptoms were assessed using the Korean version of Beck Anxiety Inventory. Logistic regression was used to estimate the odds ratio (ORs) of anxiety symptoms by serum vitamin D and CRP levels. The regression was adjusted for covariates, and each model was adjusted mutually fo...
Source: Psychiatry Investigation - Category: Psychiatry Tags: Psychiatry Investig Source Type: research
Conclusions: For HF-WBI, doses to nTIB over the prescription predicted acute toxicities independent of breast doses. These data support inclusion of TIB as a region of interest in treatment planning and protocol design. PMID: 32214909 [PubMed]
Source: Pain Physician - Category: Anesthesiology Authors: Tags: Rep Pract Oncol Radiother Source Type: research
Conclusions: According to these characteristics, tapentadol appears suitable in the treatment of severe uncontrolled chronic pain characterized by both a nociceptive and a neuropathic component, such as osteoarthritis or back pain. PMID: 32216591 [PubMed - as supplied by publisher]
Source: Current Medical Research and Opinion - Category: Research Tags: Curr Med Res Opin Source Type: research
Conclusion: Our data suggest that peripartum exposure to neuraxial anesthesia may reduce the risk of childhood asthma primarily in males. Larger human studies and model systems with longer follow-up are required to elucidate these findings. PMID: 32212939 [PubMed - as supplied by publisher]
Source: Current Medical Research and Opinion - Category: Research Tags: Curr Med Res Opin Source Type: research
Longer, lighter days can help us banish old habits, sleep better and improve our mental health, even during the lockdownThank goodness that, in this time of crisis, it is now spring. In the northern hemisphere, at least, we can say hello to green shoots, flowers, bumblebees and butterflies. Finally, the clocks have gone back to British Summer Time. We ’ve lost an hour of sleep, but hello, light.The greatest hope for the new season this year isthatbetter weather will start to makeit harder for coronavirus to spread. And for those lucky enough to still have their health, spring can provide other consolations. Its stron...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Health & wellbeing Life and style Mental health Coronavirus outbreak Infectious diseases World news Society Fitness Gardens UK news UK weather Medical research Science Psychology Source Type: news
Authors: Trivedi MH Abstract Antidepressant medications and psychotherapies can help many patients with major depressive disorder (MDD), yet millions of primary care patients do not receive effective treatment. Patients with MDD often experience side effects, inadequate response, and residual symptoms that interfere with functioning, all of which can lead to discontinuation. To improve patient outcomes, clinicians can implement strategies of measurement-based care to regularly assess depressive symptoms, treatment adherence, and adverse effects to make informed treatment decisions. Patient education and involvement...
Source: Journal of Clinical Psychiatry - Category: Psychiatry Tags: J Clin Psychiatry Source Type: research
Authors: Trivedi MH Abstract Depression is one of the most common mental disorders, affecting more than 300 million people of all ages globally, and is now the leading cause of disability. Despite the availability of effective psychological and pharmacologic treatments, depression recognition and treatment rates remain low. Clinicians can improve the recognition, diagnosis, and treatment of depression by using a measurement-based care approach. The systematic use of validated screening tools can improve recognition and diagnosis. The US Preventive Services Task force recommends routine screening of depression in ad...
Source: Journal of Clinical Psychiatry - Category: Psychiatry Tags: J Clin Psychiatry Source Type: research
Authors: Lindgren M, Holm M, Markkula N, Härkänen T, Dickerson F, Yolken RH, Suvisaari J Abstract Common infectious agents, such as Toxoplasma gondii (T. gondii) and several human herpes viruses, have been linked to increased risk of self-harm. The aim of this study was to investigate the associations between self-harm and seropositivity to T. gondii, Epstein-Barr virus (EBV), Herpes Simplex virus Type 1 (HSV-1), and Cytomegalovirus (CMV). IgM and IgG antibodies to these infections were measured in the Health 2000 project nationally representative of the whole Finnish adult population, and 6250 participan...
Source: European Archives of Psychiatry and Clinical Neuroscience - Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research
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