Bone turnover markers are differentially affected by pre-analytical handling

ConclusionsFor the bone turnover markers P1NP and BAP, the use of both plasma and serum is recommended. Samples for CTX analysis should be taken as EDTA plasma. Samples for osteocalcin analysis can be taken in either type of plasma or serum, but should be analyzed within 3  h or preserved at − 18 °C.
Source: Osteoporosis International - Category: Orthopaedics Source Type: research