Inhibited Production of iNOS by Murine J774 Macrophages Occurs via a phoP-Regulated Differential Expression of NFκB and AP-1.
Conclusion. S. typhimurium inhibit NFκB and AP-1 interaction with macrophage DNA via the PhoP regulon, this reduces nitrite ion production and is principally associated with typhoidal serovars. PMID: 22848212 [PubMed]
Keeler Family Farms of Deming, NM is voluntarily recalling red, yellow, and white onions shipped from July 1, 2021 through August 25, 2021 that were imported from Chihuahua, MX. The onions are recalled because they have the potential to be contaminated with Salmonella. Salmonella, is an organism t
It turns out that Salmonella Oranienburg outbreak from a previously unknown food source has an onion ring to it.
The Canadian Food Inspection Agency (CFIA) has issued a recall warning for whole red, yellow and white raw onions after U.S. health officials linked the vegetables to a salmonella outbreak that has sickened more than 650 people in 37 U.S. states.
In this study, we examine the roles of three major kinases viz. p38 MAPK, ERK, and STAT3 in regulating iNOS expression and thereby the levels of the free radical Nitric oxide in senescent cells. Our study revealed that these kinases could differentially regulate iNOS in senescent cells compared to non-senescent cells. Further, we tested the physiological relevance of these alterations with Salmonella infection assays and established an inter-regulatory network between these kinases unique to infected senescent cells. Overall, our findings show how key signalling networks may be rewired in senescent cells rendering them phe...
U.S. health officials say a salmonella outbreak tied to onions has sickened more than 650 people in 37 states
Title: Salmonella Outbreak in 37 States Linked to OnionsCategory: Health NewsCreated: 10/21/2021 12:00:00 AMLast Editorial Review: 10/21/2021 12:00:00 AM
The CDC is urging Americans to " throw away any unlabeled unions " from Mexico as officials investigate an outbreak of salmonella linked to the Mexican-imported vegetable that has sickened hundreds.
ConclusionThe recommended IV dose of 10 mg/kg q8h, not exceeding 400 mg q8h, would achieve AUC0-24 h to successfully treat bacteria with MICs ≤ 0.25 (e.g. Salmonella, Escherichia coli, Proteus, Haemophilus, Enterobacter, and Klebsiella). A dose increase to 600 mg q8h in children > 40 kg and to 15 mg/kg q8h (max 400 mg q8h, max 600 mg q8h if augmented renal clearance, i.e., eGFR > 200 mL/min/1.73 m2) in children
In this study, phages against three bacterial genera were isolated using three different enrichment methods. Host range profiles of the isolated phages were quantitatively determined using a high throughput turbidimetric protocol and the data were analyzed with an accessible analytic tool “PHIDA”. Using this tool, the host ranges of 9 Listeria, 14 Salmonella, and 20 Pseudomonas phages isolated with different enrichment methods were quantitatively compared. A high variability in the host range index (HRi) ranging from 0.86–0.63, 0.07–0.24, and 0.00–0.67 for Listeria, Salmonella, and Pseudomonas...
Calf diarrhea is one of the most concerning challenges facing both the dairy and beef cattle industry. Maintaining healthy gut microbiota is essential for preventing gastrointestinal disorders. Here, we observed significantly less bacterial richness in the abnormal feces with watery or hemorrhagic morphology compared to the normal solid feces. The normal solid feces showed high relative abundances of Osllospiraceae, Christensenellaceae, Barnesiella, and Lactobacillus, while the abnormal feces contained more bacterial taxa of Negativicutes, Tyzzerella, Parasutterella, Veillonella, Fusobacterium, and Campylobacter. Healthy c...