The ‘obesity paradox’ in action with cancer immunotherapy

The ‘obesity paradox’ in action with cancer immunotherapyThe ‘obesity paradox’ in action with cancer immunotherapy, Published online: 22 January 2019; doi:10.1038/s41574-019-0161-2A recent study has shown that obesity and ageing induce T cell dysfunction and an upregulation of programmed cell death 1 (PD-1) on T cells across species, which is partially mediated by leptin. However, the polarization of T cells towards an exhaustive phenotype correlated with improved response rates to anti-PD-1 therapy in the setting of obesity.

Source: Nature Reviews Endocrinology - January 22, 2019 Category: Endocrinology Authors: Joanne Lysaght Source Type: research