Abstract #12: tDCS effects on appetite are influenced by COMT genotype status in young women with obesity

Introduction: Obesity is associated with dysregulation in front-striatal brain regions. Transcranial direct current stimulation (tDCS) targeted to the dorsolateral prefrontal cortex (DLPFC) could reverse these abnormalities and potentially benefit patients trying to lose weight. To date, however, the experience with tDCS in the context of appetite, food intake and obesity suggests high response variability across individuals. Differences in dopamine neurotransmission may play a role, as they have been linked to tDCS plasticity mechanisms as well as obesity pathophysiology.

Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - January 22, 2019 Category: Neurology Authors: Priscila Giacomo Fassini, Sai Krupa Das, Vivian Marques Miguel Suen, Greta Magerowski, Wilson Ara újo da Silva Junior, Júlio Sérgio Marchini, Miguel Alonso-Alonso Source Type: research