DNA methylation of the Rtl1 promoter in the placentas with fetal growth restriction

Small for gestational age (SGA) babies experience fetal growth restriction because of placental insufficiency, and aberrant fetal growth has been linked to DNA methylation in the placenta. An imprinted gene encoding retrotransposon-like protein 1 (RTL1) is regulated by DNA methylation in the promoter region and plays a key role in placental development. We therefore investigated the DNA methylation status of RTL1 in the placenta of infants with severe SGA.

Source: Pediatrics and Neonatology - January 21, 2019 Category: Perinatology & Neonatology Authors: Kazumichi Fujioka, Kosuke Nishida, Mariko Ashina, Shinya Abe, Sachiyo Fukushima, Toshihiko Ikuta, Shohei Ohyama, Ichiro Morioka, Kazumoto Iijima Tags: Original Article Source Type: research