Changes in proinflammatory gene expression in human whole blood after contact with UV-conditioned implant surfaces

ConclusionsDifferences in the gene expression of proinflammatory cytokines after insertion of UV-conditioned titanium implants can be assessed using a human whole blood test. UV-conditioned implant surfaces apparently suppress the release ofIL1B in vitro.Clinical relevanceThe results of our publication demonstrate that modulation of the early inflammatory response in human whole blood is possible by surface treatment with UV light. In particular, the suppression ofIL1B expression, especially after the initial contact of blood cells, may be beneficial in the osseointegration of titanium implants by positively influence the balance between rejection and acceptance of an implant.

Source: Clinical Oral Investigations - January 21, 2019 Category: Dentistry Source Type: research