Serum Procalcitonin and Presepsin Levels in Patients with Generalized Pustular Psoriasis.

Serum Procalcitonin and Presepsin Levels in Patients with Generalized Pustular Psoriasis. Dis Markers. 2018;2018:9758473 Authors: Nagai M, Imai Y, Wada Y, Kusakabe M, Yamanishi K Abstract Patients with generalized pustular psoriasis (GPP) often present with symptoms that must be differentiated from sepsis. Procalcitonin (PCT) and presepsin (P-SEP) are widely used as biomarkers for sepsis; therefore, we examined the serum PCT and P-SEP levels in patients with psoriatic diseases. The enrolled patients included 27 with psoriasis vulgaris (PV) (22 males, 5 females; mean age 47.7 years), 12 with psoriatic arthritis (PsA) (8 males, 4 females; mean age 51.3 years), and 15 with GPP (10 males, 5 females; mean age 63.7 years). The mean serum PCT levels in patients with PV, PsA, and GPP were 0.01 ng/mL (25th-75th percentile; 0.00-0.03), 0.013 ng/mL (0.00-0.03), and 0.12 ng/mL (0.05-0.18), respectively; the levels of PCT were higher for patients with GPP than with PV or PsA but were lower than the PCT cutoff value (0.5 ng/mL) for the diagnosis of infection. The mean serum P-SEP levels in patients with PV, PsA, and GPP were 144.9 pg/mL (25th-75th percentile; 78-181), 168.1 pg/mL (124-203), and 479.9 pg/mL (216-581), respectively. Unexpectedly, the levels of P-SEP in the patients with GPP were as high as the P-SEP cutoff value (317 to 647 pg/mL) used for the diagnosis of infection. We also found that neutrophils produced P-SEP, sug...
Source: Disease Markers - Category: Laboratory Medicine Tags: Dis Markers Source Type: research