A New Era for Chronic Management of Hypoparathyroidism: Parathyroid Hormone Peptides.
A New Era for Chronic Management of Hypoparathyroidism: Parathyroid Hormone Peptides.
Front Horm Res. 2019;51:165-171
Authors: Marcucci G, Brandi ML
Abstract
Several studies have investigated replacement therapy with recombinant human parathyroid hormone [rhPTH(1-84)] for patients affected by chronic hypoparathyroidism who are not adequately controlled with standard treatment. In 2015, the Food and Drug Administration (FDA) in the USA approved rhPTH(1-84), named Natpara®, for the pharmacological management of hypoparathyroidism. In Europe, in February 2017, the European Medicines Agency (EMA) recommended granting a conditional marketing authorization in the European Union for rhPTH(1-84). Here we review the studies conducted with rhPTH(1-84) and PTH(1-34) in patients with chronic hypoparathyroidism. The research done in this field has shown that replacement treatment with rhPTH(1-84) is an important therapeutic option for subjects with chronic hypoparathyroidism who are not well controlled with conventional treatment. However, further long-term investigations are needed.
PMID: 30641529 [PubMed - in process]
Source: Frontiers of Hormone Research - Category: Endocrinology Tags: Front Horm Res Source Type: research
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