DNA damage and genome instability by G-quadruplex ligands are mediated by R loops in human cancer cells [Biochemistry]

G quadruplexes (G4s) and R loops are noncanonical DNA structures that can regulate basic nuclear processes and trigger DNA damage, genome instability, and cell killing. By different technical approaches, we here establish that specific G4 ligands stabilize G4s and simultaneously increase R-loop levels within minutes in human cancer cells. Genome-wide...

Source: Proceedings of the National Academy of Sciences - January 15, 2019 Category: Science Authors: Alessio De Magis, Stefano G. Manzo, Marco Russo, Jessica Marinello, Rita Morigi, Olivier Sordet, Giovanni Capranico Tags: PNAS Plus Source Type: research