Hormone Therapy May Protect Against Knee Osteoarthritis Hormone Therapy May Protect Against Knee Osteoarthritis
Postmenopausal women taking hormone therapy were significantly less likely to develop symptomatic knee osteoarthritis compared with those who did not take hormone therapy, a large study has found.Medscape Medical News
Arthritis is more common in women and often presents around the time of the menopause or in later life. Common causes of arthralgia (joint pain in the absence of arthritis) and arthritis in this population are discussed, notably osteoarthritis and rheumatoid arthritis. The clinical assessment, investigation and management of women presenting with arthralgia or arthritis will be reviewed. The epidemiological and trials evidence for the effects of menopausal hormonal therapy (MHT) on joint pain, osteoarthritis and rheumatoid arthritis will be discussed.
In this study, we found that senescent chondrocytes isolated from OA patients secrete more EVs compared with nonsenescent chondrocytes. These EVs inhibit cartilage ECM deposition by healthy chondrocytes and can induce a senescent state in nearby cells. We profiled the miR and protein content of EVs isolated from the synovial fluid of OA joints from mice with SnCs. After treatment with a molecule to remove SnCs, termed a senolytic, the composition of EV-associated miR and protein was markedly altered. The senolytic reduced OA development and enhanced chondrogenesis, and these were attributable to several specific differenti...
THURSDAY, Jan. 17, 2019 -- For postmenopausal women, the prevalence of knee osteoarthritis is lower with menopausal hormone therapy (MHT) use, according to a study published online Dec. 21 in Menopause. Jae Hyun Jung, M.D., Ph.D., from the Korea...
Research, published inMenopause, suggests that women who receive hormone therapy have a lower risk of developing osteoarthritis.Science Daily
(The North American Menopause Society (NAMS)) There is an ongoing debate regarding the relationship between knee osteoarthritis and hormone therapy (HT), with small-scale studies providing mixed results. A new large-scale study from Korea shows that women receiving HT had a significantly lower prevalence of symptomatic knee osteoarthritis compared with women who did not take hormones. Study results are published online in Menopause, the journal of The North American Menopause Society (NAMS).
Authors: Abstract PMID: 30600980 [PubMed - in process]
CONCLUSION: Acupuncture is a safe and viable nonpharmacologic treatment that may relieve joint pain in patients with AIA. Additional studies involving a higher number of RCTs are warranted. PMID: 28384564 [PubMed - as supplied by publisher]
Purpose Arthralgia occurs in up to 50% of breast cancer survivors treated with aromatase inhibitors (AIs) and is the most common reason for poor AI adherence. We conducted, in 121 breast cancer survivors receiving an AI and reporting arthralgia, a yearlong randomized trial of the impact of exercise versus usual care on arthralgia severity. Patients and Methods Eligibility criteria included receiving an AI for at least 6 months, reporting ≥ 3 of 10 for worst joint pain on the Brief Pain Inventory (BPI), and reporting
From MedPage Today: Kid’s Asthma Not Linked to Maternal SSRIs in Pregnancy. Children whose depressed mothers took newer antidepressants while pregnant were not at increased risk of childhood asthma. Menopausal HT Not Tied to Greater Death Risk. Hormone therapy in postmenopausal women was not linked to a significant effect on all-cause mortality, cardiovascular death, or breast cancer death. In Cancer Wars, It’s Doctors vs. Hospitals. Colliding federal policies are fomenting a nasty money war that’s pitting community oncologists trying to treat patients in less expensive clinic settings against hospi...