Reading the signs: Semaphorin linked to lung cancer treatment resistance

(Osaka University) Osaka University researchers showed that high levels of the protein Semaphorin 7a are associated with resistance to treatment with EGFR-TKIs in lung adenocarcinoma cells with EGFR mutation. The findings revealed the involvement of mTOR signaling in this effect, as well as the importance of the inhibition of apoptosis. The findings suggest that focusing on Semaphorin 7a could be advantageous for predicting the prognosis of lung cancer patients and potentially for treating them.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news