Low-Pass Whole-Genome Sequencing of Circulating Cell-Free DNA Demonstrates Dynamic Changes in Genomic Copy Number in a Squamous Lung Cancer Clinical Cohort.

CONCLUSION: LP-WGS offers an unbiased and high-throughput way to investigate CNVs and tumor fraction in cfDNA of cancer patients. It may also be valuable for monitoring treatment response, detecting disease progression early, and identifying emergent clones associated with therapeutic resistance.
PMID: 30617129 [PubMed - as supplied by publisher]

Source: Clinical Cancer Research - January 7, 2019 Category: Cancer & Oncology Authors: Chen X, Chang CW, Spoerke JM, Yoh K, Kapoor V, Baudo CD, Aimi J, Yu M, Liang-Chu MMY, Suttman R, Huw LY, Gendreau S, Cummings CA, Lackner MR Tags: Clin Cancer Res Source Type: research