Synthesis, Structural Characterization, Electrochemical, Photoluminescence, Antiproliferative and Antioxidant Properties of Co(II), Cu(II) and Zn(II) Complexes Bearing the Azo-Azomethine Ligands

Publication date: Available online 8 January 2019Source: Journal of Molecular StructureAuthor(s): Esin Ispir, Mesut Ikiz, Ayşe Inan, Ali Burak Sünbül, Seçil Erden Tayhan, Sema Bilgin, Muhammet Köse, Mahfuz ElmastaşAbstractCo(II), Cu(II) and Zn(II) complexes derived from azo-azomethine compounds were synthesized and characterized by a combination of magnetic susceptibility, elemental analyses, FTIR and UV-Visible spectroscopies. The characterized complexes were found to be mononuclear and the chelation of the ligands to the metal ions occurs through phenolic oxygen and nitrogen atoms of the azomethine group of the ligands. Solid state structure of 5 was determined by single crystal X-ray diffraction studies. The electrochemical and photoluminescence properties of the synthesized compounds were also studied.In order to evaluate the ability of the compounds to inhibit cell proliferation, we treated MCF7 (breast cancer), PC3 (prostate cancer) and H2126 (lung cancer) cells with different concentrations of Co(II), Cu(II) and Zn(II) complexes bearing the azo-azomethine ligands. When nine Co(II), Cu(II) and Zn(II) complexes were assessed within themselves, our results highlighted that three compounds (8, 9 and 10) had the best inhibitory activity on all cell lines.

Source: Journal of Molecular Structure - January 9, 2019 Category: Molecular Biology Source Type: research