Selective loss of levator ani and leg muscle volumes in men undergoing androgen deprivation therapy.

Conclusion: Androgen responsiveness of levator ani appears to be evolutionarily conserved in humans. ADT selectively decreases volume of muscles that support body weight. Interventional strategies to reduce ADT-related sarcopenia and sexual dysfunction should assess whether targeting these muscle groups, including the pelvic floor improves clinical outcomes.
PMID: 30602021 [PubMed - as supplied by publisher]

Source: The Journal of Clinical Endocrinology and Metabolism - December 31, 2018 Category: Endocrinology Authors: Cheung AS, Cunningham C, Ko DD, Ly V, Gray H, Hoermann R, Strauss BJG, Hassan EB, Duque G, Ebeling P, Pandy MG, Zajac JD, Grossmann M Tags: J Clin Endocrinol Metab Source Type: research