Comparative Analysis of the Histopathologic Features, β -Catenin, and Ki67 Expression between Fibromatosis and Fibrosarcoma

Conclusion: The present findings suggest the mitotic figures, Ki67, herringbone pattern, cellularity, and atypia are useful to differentiate fibromatosis from fibrosarcoma.Statement of the Problem: The Biologic behavior and histopathological features of fibromatosis are intermediate between those of fibroma and fibrosarcoma.Purpose: The aim of the present study was to determine useful histopathologic and immunohistochemical characteristics for the differentiation of these lesions.Materials and Method: In this cross-sectional descriptive study, 40specimens comprising20 fibrosarcoma and20 fibromatosis biopsies were selected.The histopathologic characteristicsof these lesionswere identified andimmunohistochemical staining forKi67andĪ²-catenin markers was performed.Sectionswereexaminedby light microscopy andpositivelystainedcellswere counted.Resultswereanalyzedby SPSS 20 usingChi-square test, Mann-whitneytest, and t-test(p< 0.05).Results: Statistical significant differences were observed between fibromatosis and fibrosarcoma in terms of distribution frequency, mitotic rate, and herringbone pattern, cellularity, overlapping of nuclei, mean Ki67 score, and atypia rate. The other features including age, gender, necrosis, clarity of nucleoli and meanĪ²-catenin were not significantly different.Conclusion: The present findings suggest the mitotic figures, Ki67, herringbone pattern, cellularity, and atypia are useful to differentiate fibromatosis from fibrosarcoma.
Source: Journal of Dentistry, Shiraz University of Medical Sciences - Category: Dentistry Source Type: research