The immune-modulation and gut microbiome structure modification associated with long-term dietary supplementation of Lactobacillus rhamnosus using 16S rRNA sequencing analysis

Publication date: February 2019Source: Journal of Functional Foods, Volume 53Author(s): Yaser Gamallat, Xiaomeng Ren, Abdo Meyiah, Meiqi Li, Xinxiu Ren, Yazeed Jamalat, Siyuan Song, Luhan Xie, Bashir Ahmad, Abdullah Shopit, Haithm Mousa, Yufang Ma, Yi Xin, Dapeng DingAbstractProbiotic dietary supplementation plays a crucial role in shaping gut microbiota and boost immune-responses. We herein investigated the potential effect of long-term dietary-supplementation of Lactobacillus rhamnosus (LBR) on gut microbiome structure, metabolome functions, and serum-profile. Our results revealed, LBR long-term supplementation reduces the body weight gain, ameliorates serum cytokines and attenuates serum lipoproteins profile. Moreover, LBR enhances biofilms-aerobics. Gut microbiome 16S rRNA analysis revealed LBR intervention significantly increased the relative abundance of Limnobacter, Turicibacterales, Enterococcus, and Vagococcus. On the contrary, the abundance of Helicobacteraceae, Rikenellaceae, Roseburia, Dorea, Anaerostipes, Coprococcus, Lachnospira, Oscillospira, Ruminococcaceae, Clotridiales, S24_7, Bacteroidia and Bacteroidetes found decreased in LBR treated group. Functional comparison revealed LBR exhibited higher level of energy production and conversion, amino acid transport and metabolism functions. Our findings demonstrate that the LBR dietary supplementation found to be beneficially modulating the immune-response, enhances lipoprotein metabolism, and ameliorates the microb...
Source: Journal of Functional Foods - Category: Nutrition Source Type: research