Epigenetic silencing of miRNA-338-5p and miRNA-421 drives SPINK1-positive prostate cancer.

CONCLUSION: Our findings revealed that miRNA-338-5p/-421 are epigenetically silenced in SPINK1-positive PCa, while restoring the expression of these miRNAs using epigenetic drugs or synthetic mimics could abrogate SPINK1-mediated oncogenesis.
PMID: 30587549 [PubMed - as supplied by publisher]

Source: Clinical Cancer Research - December 26, 2018 Category: Cancer & Oncology Authors: Bhatia V, Yadav A, Tiwari R, Nigam S, Goel S, Carskadon S, Gupta N, Goel A, Palanisamy N, Ateeq B Tags: Clin Cancer Res Source Type: research