Evaluation of sperm telomere length in infertile men with failed fertilization after intra-cytoplasmic sperm injection

ConclusionsLow or failed fertilization rate could be related to oxidative stress resulting in short telomere length, and also increased sperm chromatin damage and lipid peroxidation. Based on literature, shortened telomere length may lead to detachment of chromosomes from nuclear membrane, the consequences of which are: defect in process of spermatogenesis, pronuclei formation, and delayed or arrested cell cycle post-ICSI.
Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research