Modelling spatio-temporal data of dengue fever using generalized additive mixed models

This study brings together a large dataset from different sources including Ministry of Health from Venezuela. It was also benefited from a remote satellite climatic data provided by the National Aeronautics and Space Administration (NASA).
Source: Spatial and Spatio-temporal Epidemiology - Category: Epidemiology Source Type: research

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West Nile (WN) virus infection of humans is frequently asymptomatic, but can also lead to WN fever or neuroinvasive disease. CD4 T cells and B cells are critical in the defense against WN virus, and neutralizing antibodies, which are directed against the viral glycoprotein E, are an accepted correlate of protection. For the efficient production of these antibodies, B cells interact directly with CD4 helper T cells that recognize peptides from E or the two other structural proteins (capsid-C and membrane-prM/M) of the virus. However, the specific protein sites yielding such helper epitopes remain unknown. Here, we explored ...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
A dengue fever outbreak that has affected thousands of Paraguayans in recent weeks has reached as far as the presidential palace, with the country's leader Mario Abdo confirmed as having been struck by the disease.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
(University of Leeds) A skin cream used to treat warts and skin cancer could help protect people against viral diseases such as Zika and dengue, according to new research from the University of Leeds.
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news
AbstractGuillain –Barré syndrome (GBS) is an acute-onset, immune-mediated polyradiculoneuropathy, often precipitated by an antecedent infection. An association of GBS with vector-borne viral infections has been suggested, with evidence for the involvement of Zika, Dengue, Chikungunya and West Nile virus (WNV). Th is prospective case–control study was conducted to identify vector-borne viral infections in GBS. Thirteen individuals newly diagnosed as GBS were enrolled. Disease severity, prognostic factors and nerve conduction patterns were assessed. Eleven individuals with non-infectious conditions requiri...
Source: Acta Neurologica Belgica - Category: Neurology Source Type: research
Dengue is a life-threatening disease that occurs mostly in children and is endemic in tropical and subtropical regions worldwide. It is a mosquito-borne disease caused by dengue virus, which belongs to the family Flaviviridae. Dengue is transmitted by Aedes-type mosquitoes, primarily A. aegypti. There are four dengue virus serotypes: DENV-1, DENV-2, DENV-3, and DENV-4 (Srikiatkhachorn and Kelley, 2014). The clinical manifestations of dengue infection can be asymptomatic; mild (dengue fever (DF)), involving only fever; severe (dengue hemorrhagic fever (DHF)), which involves subcutaneous bleeding detectable by tourniquet tes...
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Source Type: research
Publication date: Available online 20 January 2020Source: Sensors and Actuators A: PhysicalAuthor(s): Nur Alia Sheh Omar, Yap Wing Fen, Silvan Saleviter, Yasmin Mustapha Kamil, Wan Mohd Ebtisyam Mustaqim Mohd Daniyal, Jaafar Abdullah, Mohd Adzir MahdiAbstractThe plethora of optical techniques have been developed to detect the dengue virus, regrettably, the existing techniques are cumbersome and have limitations to provide early identification of the low-level of dengue virus. For this purpose, surface plasmon resonance (SPR) optical sensor was designed with a highly sensitive thin film based on hyperbranched polymer nanoco...
Source: Sensors and Actuators A: Physical - Category: Physics Source Type: research
There was nothing quite like the slang used in the early days of the space program. Saying something was “OK” would not do when you could say “A-OK” instead. Saying, “Let’s get moving,” when you’ve been sealed in your spacecraft for hours waiting to launch while Mission Control sorts out technical glitches, was weak tea compared to the “Light this candle!” as an exasperated Al Shepard barked in 1961. And then, too, there was “screw the pooch.” A cleaned-up version of a decidedly coarser term, it meant, in the pilot’s argot, to crash your jet or l...
Source: TIME: Science - Category: Science Authors: Tags: Uncategorized climate change newsletter Space Source Type: news
Researchers have reported that a new vaccine against the dengue virus protected children and adolescents in a phase 3 trial conducted in Asia and Latin America.
Source: JAMA - Category: General Medicine Source Type: research
This study aimed to compare the short-term temperature-dengue associations during different dengue outbreak periods, estimate the den gue cases attributable to temperature, and ascertain if there was an association between heatwaves and dengue outbreaks in Hanoi, Vietnam. Methodology/Principal findingsDengue outbreaks were assigned to one of three categories (small, medium and large) based on the 50th, 75th, and 90th percentiles of distribution of weekly dengue cases during 2008 –2016. Using a generalised linear regression model with a negative binomial link that controlled for temporal trends, temperature variation,...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
Conclusions/SignificanceAchieving high uptake and compliance with PPT in populations most at risk of adverse outcomes from Zika infection requires engaging key users in open dialogue to identify and address any practical issues regarding PPT use, and concerns over safety. The findings presented here suggest that educational campaigns should strongly emphasize the risks associated with Zika during pregnancy, and discuss safety profiles of approved synthetic repellents and the availability of EPA-approved plant-based repellents. In addition, the economic and political context should be a major consideration when evaluating p...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
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