Reply

We thank Dr Hofmann for his interest, kind comments on our work, and for the valuable points for discussion. We also appreciate the difficulty mentioned regarding optimal stool sampling for bile acid (BA) analysis. This would have been even more important if we had observed no significant change in fecal BAs. On the other hand, we actually showed reduced deoxycholic acid (DCA) in stool from patients with constipation-predominant irritable bowel syndrome (IBS-C). Our methods were based on high-performance liquid chromatography with tandem mass spectrometry.
Source: Clinical Gastroenterology and Hepatology - Category: Gastroenterology Authors: Tags: Letter to the Editor Source Type: research