We thank Dr Hofmann for his interest, kind comments on our work, and for the valuable points for discussion. We also appreciate the difficulty mentioned regarding optimal stool sampling for bile acid (BA) analysis. This would have been even more important if we had observed no significant change in fecal BAs. On the other hand, we actually showed reduced deoxycholic acid (DCA) in stool from patients with constipation-predominant irritable bowel syndrome (IBS-C). Our methods were based on high-performance liquid chromatography with tandem mass spectrometry.
Source: Clinical Gastroenterology and Hepatology - Category: Gastroenterology Authors: Tags: Letter to the Editor Source Type: research

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ConclusionThe prevalence of anti tTG antibodies in irritable bowel syndrome is high. Patients with D-IBS should be screened for celiac disease.ResumoIntroduçãoA síndrome do intestino irritável (SII) é um distúrbio gastrointestinal comum; a doença celíaca é uma enteropatia autoimune que pode imitar qualquer distúrbio gastrointestinal funcional. O objetivo deste estudo foi estimar a prevalência de anticorpos contra a doença celíaca (antitransglutaminase tecidual - tTG) em pacientes com SII.Pacientes e MétodosEste estudo transvers...
Source: Journal of Coloproctology - Category: Gastroenterology Source Type: research
FREMONT, Calif., Sept. 12, 2019 /PRNewswire/ -- Ardelyx, Inc. today announced that the U.S. Food and Drug Administration has approved Ibsrela (tenapanor), a 50 mg, twice daily oral pill for the treatment of irritable bowel syndrome with constipation...
Source: - New Drug Approvals - Category: Drugs & Pharmacology Source Type: news
Purpose of review There is growing evidence encouraging the use of probiotics in many conditions in children. However, given the wide number of probiotics available and contradictory data in the literature, the health-care provider is often faced with uncertainness about whether or not to use probiotics and which one(s) to choose. We here review current hypotheses regarding the efficacy and safety of probiotics and evaluate the available data on the use of probiotics in most common diseases in children. Considering that probiotics have strain-specific effects, we will focus on individual probiotic strains rather than on ...
Source: Current Opinion in Pediatrics - Category: Pediatrics Tags: GASTROENTEROLOGY AND NUTRITION: Edited by Bradley Barth Source Type: research
Conclusions: Altered bowel habits are a consequence of CDI and are common after FMT. This study suggests that donor type and FMT delivery modality are not related to the presence of irregular gastrointestinal symptoms after FMT.
Source: Journal of Clinical Gastroenterology - Category: Gastroenterology Tags: ONLINE ARTICLES: Original Articles Source Type: research
CONCLUSIONS: The results for the outcomes assessed in this review are uncertain. Thus no firm conclusions regarding the effectiveness and safety of homeopathy for the treatment of IBS can be drawn. Further high quality, adequately powered RCTs are required to assess the efficacy and safety of clinical and individualised homeopathy for IBS compared to placebo or usual care. PMID: 31483486 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - Category: General Medicine Authors: Tags: Cochrane Database Syst Rev Source Type: research
Gastrointestinal (GI) motility disorders are major contributing factors to functional GI diseases that account for>40% of patients seen in gastroenterology clinics and affect>20% of the general population. The autonomic and enteric nervous systems and the muscles within the luminal GI tract have key roles in motility. In health, this complex integrated system works seamlessly to transport liquid, solid, and gas through the GI tract. However, major and minor motility disorders occur when these systems fail. Common functional GI motility disorders include dysphagia, gastroesophageal reflux disease, functional dyspepsia...
Source: Cold Spring Harbor perspectives in medicine - Category: Research Authors: Tags: Bioelectronic Medicine TECHNIQUES Source Type: research
Publication date: Available online 28 August 2019Source: Journal of the Academy of Nutrition and DieteticsAuthor(s): Lin Wang, Nuha Alammar, Rajdeep Singh, Julie Nanavati, Yiran Song, Rahul Chaudhary, Gerard E. MullinAbstractBackgroundIrritable bowel syndrome (IBS) is the most common functional digestive condition in the industrialized world. The gut microbiota plays a key role in disease pathogenesis.ObjectiveA systematic review and meta-analysis on case–control studies was conducted to determine whether there is gut microbial dysbiosis in participants with IBS in comparison with healthy controls and, if so, whether...
Source: Journal of the Academy of Nutrition and Dietetics - Category: Nutrition Source Type: research
AbstractWe hypothesized that DSP ‐6952, a partial agonist of the 5‐hydroxytryptamine type‐4 receptor and a gastrointestinal prokinetic agent, can induce natural bowel movements by enhancing gastrointestinal motility and colonic transit in patients with chronic constipation and irritable bowel syndrome with constipation. This 3‐part phase 1 study evaluated the safety, tolerability, and pharmacokinetic and pharmacodynamic profiles of DSP‐6952. Eighty‐eight Japanese subjects (64 healthy volunteers and 24 subjects with spontaneous bowel movements ≤3 times/wk) were randomized to DSP‐6952 or placebo. The overall...
Source: Clinical Pharmacology in Drug Development - Category: Drugs & Pharmacology Authors: Tags: Original Manuscript Source Type: research
ConclusionsIn Japan, among the population of under 70  years old, the prevalence of IBS-C and FC (Rome III criteria) was 4.97% and 8.76%, respectively. IBS-C caused more severe symptoms than FC, resulting in impairment of QOL.
Source: Journal of Gastroenterology - Category: Gastroenterology Source Type: research
Source: Clinical and Experimental Gastroenterology - Category: Gastroenterology Tags: Clinical and Experimental Gastroenterology Source Type: research
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