Direct HLA Genetic Comparisons Identify Highly Matched Unrelated Donor/Recipient Pairs with Improved Transplant Outcome

Consistent with their role in immune recognition, HLA genes are the most polymorphic loci in the human genome. Within the HLA genes, the highest degree of genetic polymorphism is found within a few exons that encode the peptide and T cell receptor binding regions of the HLA proteins (also termed antigen recognition domains) [1]. For HLA class I proteins (HLA-A, -B, and -C), exons 2 and 3 encode the peptide binding site, while exon 2 encodes the peptide binding site for HLA class II proteins (HLA-DR, -DQ, and -DP).

Source: Biology of Blood and Marrow Transplantation - December 8, 2018 Category: Hematology Authors: Ibrahim Vazirabad, Saurabh Chhabra, James Nytes, Vatsal Mehra, Ravi K. Narra, Aniko Szabo, James H. Jerkins, Binod Dhakal, Parameswaran Hari, Matthew W. Anderson Source Type: research