Exosomal microRNA-21 derived from bronchial epithelial cells is involved in aberrant epithelium-fibroblast cross-talk in COPD induced by cigarette smoking

Conclusion: We demonstrate that CS triggers the modification of exosome components and identify miR-21 derived from bronchial epithelial cells as a mediator of myofibroblast differentiation through the pVHL/HIF-1α signaling pathway, which has potential value for diagnosis and treatment of COPD.

Source: Theranostics - December 7, 2018 Category: Molecular Biology Authors: Hui Xu, Min Ling, Junchao Xue, Xiangyu Dai, Qian Sun, Chao Chen, Yi Liu, Liang Zhou, Jianping Liu, Fei Luo, Qian Bian, Qizhan Liu Tags: Research Paper Source Type: research