Distinct transcriptomic profiles of early-onset atopic dermatitis in blood and skin of pediatric patients

Atopic dermatitis (AD) is the most common chronic inflammatory skin disease. The pipeline of novel targeted treatments for AD is expanding, largely based on our growing knowledge of disease mechanisms, with new therapeutics particularly focused on immune modulation.1 Most of our understanding of AD is derived from profiling tissues and blood of longstanding AD in adults, due to the difficulty of obtaining samples from infants and young children. However, initiation of AD typically happens very early in life, and the disease is already chronically established in the majority of patients by 5yrs of age.

Source: Annals of Allergy, Asthma and Immunology - November 30, 2018 Category: Allergy & Immunology Authors: Patrick M. Brunner, Ariel Israel, Alexandra Leonard, Ana B. Pavel, Hyun Je Kim, Ning Zhang, Tali Czarnowicki, Krishna Patel, Morgan Murphrey, Kara Ramsey, Stephanie Rangel, Rema Zebda, Vinaya Soundararajan, Xiuzhong Zheng, Yeriel D. Estrada, Hui Xu, James Source Type: research