Indacaterol and tiotropium combination therapy in patients with chronic obstructive pulmonary disease

Conclusions Indacaterol and tiotropium combination therapy improved airflow limitation and respiratory resistances. Adding indacaterol to tiotropium, or tiotropium to indacaterol, had similar effects on airflow limitation.
Source: Pulmonary Pharmacology and Therapeutics - Category: Respiratory Medicine Source Type: research

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Conclusions:We found OSA to be common and associated with worse sleep quality and less daily vitality in patients with advanced CRDs. The STOP-BANG questionnaire with different cutoff points may help rule in or rule out OSA. Overnight oximetry can be used as a screening tool for OSA and can assist the clinical evaluation of OSA in patients with CRDs.Citation:Zhang XL, Dai HP, Zhang H, Gao B, Zhang L, Han T, Wang C. Obstructive sleep apnea in patients with fibrotic interstitial lung disease and COPD.J Clin Sleep Med. 2019;15(12):1807–1815.
Source: Journal of Clinical Sleep Medicine : JCSM - Category: Sleep Medicine Source Type: research
ABSTRACT Objective: To test the construct validity, reliability, and measurement error of the Brazilian Portuguese-language version of the Manchester Respiratory Activities of Daily Living (MRADL) questionnaire in patients with COPD. Methods: We evaluated 50 patients with COPD, among whom 30 were men, the mean age was 64 ± 8 years, and the median FEV1 as a percentage of the predicted value (FEV1%predicted) was 38.4% (interquartile range, 29.1-57.4%). Pulmonary function and limitations in activities of daily living (ADLs) were assessed by spirometry and by face-to-face application of the MRADL, respectively. For the ...
Source: Jornal Brasileiro de Pneumologia - Category: Respiratory Medicine Source Type: research
ConclusionsThis study revealed that loss of teeth in adults aged ≥ 40 years was associated with COPD.
Source: International Dental Journal - Category: Dentistry Authors: Tags: Scientific Research Report Source Type: research
ConclusionThe present study demonstrates that rib fixation for multiple rib fractures or flail chest results in adequate recovery of the pulmonary function within 3  months after surgery. In addition, based on the current literature, further gradual improvement to maximum pulmonary values appears to occur during the first 12 months after rib fixation.
Source: European Journal of Trauma and Emergency Surgery - Category: Emergency Medicine Source Type: research
Conclusions: Azithromycin treatment in severe COPD patients not only improves control of exacerbations, but also achieves functional improvement in almost half of the patients, related to a reduction in inflammation.Funding: FIS (PI16 / 00977), SEPAR (88/2016), FUCAP, Menarini.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Airway pharmacology and treatment Source Type: research
Conclusions: This study showed non-inferiority of device procedure compared to CPT. Simeox ACT was considered safe and feasible for airway clearance management during hospitalization of different lung diseases with mucus retention
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Clinical Problems Source Type: research
Conclusions: Respiratory symptoms are associated with subsequent respiratory hospitalisations and death in individuals with preserved pulmonary function without known airway disease.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Epidemiology Source Type: research
Conclusion: By providing intuitive explanations, LIME builds trust for clinical application of a ML-based PFT interpretation algorithm.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: M-health/e-health Source Type: research
Introduction: Thoracic computed tomography (CT) is a clinically established diagnostic technique to detect structural pulmonary abnormalities but provides no functional pulmonary information.Objectives: The current study aims to demonstrate the use of the CT-based full-scale airway network (FAN) flow model to assess ventilation in COPD patients and to compare the modelling results obtained with hyperpolarized Xenon-129 (HPX) magnetic resonance imaging (MRI) and single-photon emission computed tomography (SPECT) imaging data.Methods: Pulmonary ventilation in nine COPD patients was modelled using the CT-based FAN flow model....
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Imaging Source Type: research
Conclusion: BODE index, CT PA/AO ratio, post-6MWT oxygen saturation, and serum ghrelin level are useful noninvasive predictors for PH in patients with COPD.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Pulmonary hypertension Source Type: research
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