High versus low dose caffeine in preterm infants

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Source: Acta Paediatrica - Category: Pediatrics Authors: Tags: Letter Source Type: research

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In this study, neonatal male and female mouse pups (C57BL/6J) were exposed to hyperoxia and lung tissues were excised on postnatal day 7 for histological analysis and tandem mass tags proteomic analysis. We found that the lung sections from the male mice following postnatal hyperoxia exposure had increased alveolar simplification, significant aberrant pulmonary vascularization and arrest in angiogenesis compared with females. Comparison of differentially expressed proteins revealed 377 proteins unique to female and 425 unique to male as well as 750 proteins in both male and female. Bioinformatics analysis suggested that se...
Source: International Journal of Medical Sciences - Category: Biomedical Science Tags: Int J Med Sci Source Type: research
Abstract BACKGROUND AND OBJECTIVES: To examine whether a parenteral mixed lipid emulsion containing fish oil reduces the incidence of cholestasis, retinopathy of prematurity (ROP) and bronchopulmonary dysplasia (BPD) in very low birth weight (VLBW, birth weight
Source: Asia Pacific Journal of Clinical Nutrition - Category: Nutrition Authors: Tags: Asia Pac J Clin Nutr Source Type: research
CONCLUSIONS: Metabolites measured as part of routine newborn screening can be used to create a metabolic vulnerability profile. These findings lay the foundation for targeted clinical monitoring and further investigation of biological pathways that may increase the risk of neonatal death or major complications in infants born preterm. IMPACT: We built a newborn metabolic vulnerability profile that could identify preterm infants at risk for major morbidity and mortality.Identifying high-risk infants by this method is novel to the field and outperforms models currently in use that rely primarily on infant characteristic...
Source: Pediatric Research - Category: Pediatrics Authors: Tags: Pediatr Res Source Type: research
In conclusion, our data suggest increased frequencies and functions of Tregs in preterm neonates which display a distinct phenotype with dynamic changes in the first weeks of life. Hence, the continued abundance of Tregs may contribute to sustained inflammation preceding the development of BPD. Functional analyses are needed in order to elucidate whether Tregs have potential as future target for diagnostics and therapeutics.
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
In the PDA-TOLERATE trial, persistent, moderate-to-large PDAs (even for several weeks) were not associated with an increased risk of BPD when infants required
Source: The Journal of Pediatrics - Category: Pediatrics Authors: Tags: Brief Reports Source Type: research
Condition:   Bronchopulmonary Dysplasia Intervention:   Device: lung recruitment maneuver (LRM) with DrageerVN500 Sponsors:   Dr. R. Adhi Teguh Perma Iskandar, Sp.A(K);   Indonesian Medical Education and Research Institute Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Bronchopulmonary dysplasia (BPD) is the most common complication of prematurity and significantly contributes to mortality and morbidity with few predictive biomarkers. Given that nitrites have been implicated...
Source: Respiratory Research - Category: Respiratory Medicine Authors: Tags: Letter to the Editor Source Type: research
Condition:   Bronchopulmonary Dysplasia Intervention:   Device: lung recruitment maneuver (LRM) with DrageerVN500 Sponsors:   Dr. R. Adhi Teguh Perma Iskandar, Sp.A(K);   Indonesian Medical Education and Research Institute Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
ConclusionOur study suggests that in infants with CDH, there is no significant difference between HFV and CMV in oxygen dependency or death.
Source: Pediatric Surgery International - Category: Surgery Source Type: research
PMID: 32936025 [PubMed - as supplied by publisher]
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - Category: Cytology Authors: Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research
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