Quercetin Decreases Th17 Production by Down-Regulation of MAPK- TLR4 Signaling Pathway on T Cells in Dental Pulpitis

Conclusion:Our results indicated that the levels of IL-17, IL-33, and IL-6 in supernatants from patients ’ cultured T cells were increased after stimulation with HMGB-1 following employing quercetin. It also could inhibit MAPK signaling pathway, which subsequently could decrease Th17 production and IL-17. Quercetin could decrease pro-inflammatory cytokines and IL-17 production.

Source: Journal of Dentistry, Shiraz University of Medical Sciences - November 24, 2018 Category: Dentistry Source Type: research