Identification of an anti-Gram-negative bacteria agent disrupting the interaction between LPS transporters LptA and LptC

The emergence of drug-resistant Gram-negative bacterial strains causes significant clinical problems because the available antibiotics for the treatment of these infections are limited [1,2]. However, the discovery of new antibiotics against Gram-negative bacteria has slowed down in recent years and cannot keep pace with the emergence of drug-resistant bacteria [3,4]. Therefore, it is urgent to identify new antimicrobial compounds against Gram-negative bacteria with novel targets [5]. The envelope of Gram-negative bacteria, such as Escherichia coli, consists of inner membrane (IM), peptidoglycan, outer membrane (OM), and the periplasmic space between IM and OM [6].

Source: International Journal of Antimicrobial Agents - November 23, 2018 Category: Drugs & Pharmacology Authors: Xuelian Zhang, Yan Li, Weiwei Wang, Jing Zhang, Yuan Lin, Bin Hong, Xuefu You, Danqing Song, Yanchang Wang, Jiandong Jiang, Shuyi Si Source Type: research