Laparoscopic Single Anastomosis Duodenal-Jejunal Bypass with Sleeve Gastrectomy (SADJB-SG): Surgical risk and long-term results

Bariatric surgery is the most effective therapy for patients with morbid obesity today [1]. However, the types of operation are still in evolving. Sleeve gastrectomy (SG) recently has quickly gained popularity as a primary bariatric surgery worldwide [2, 3]. SG plus duodeno-jejunostomy (SG-DJB) was introduced in 2007 as an alternative to Roux-en-Y gastric bypass (RYGB) because the issue of gastric cancer arising from the excluded stomach [4]. SG-DJB can be regarded as a modification of duodenal switch (DS) with short bypass limb and fewer nutritional problems [5].
Source: Surgery for Obesity and Related Diseases - Category: Surgery Authors: Tags: Original articles Source Type: research

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Weight loss after gastrectomy for gastric cancer may be the result from not only altered nutrition absorption but also systematic endocrinological changes after bariatric-like surgery. No clinical studies have evaluated the altered glucose metabolism associated with postoperative weight loss in gastric cancer patients.
Source: Surgery for Obesity and Related Diseases - Category: Surgery Authors: Tags: Original articles Source Type: research
AbstractObesity is considered as a high ‐risk susceptibility state for most metabolic disorders and is directly related to preadipocyte differentiation or adipogenesis. Long noncoding RNAs (lncRNAs) are the key factors which have regulatory functions on various critical physiological and biological processes. PVT1 was identified as an o ncogenic lncRNA which could promote angiogenesis in gastric cancer. However, the functions and molecular pathways related to PVT1 in adipogenesis had not been clarified yet. In the current study, the purpose was to identify the effects of lncRNA PVT1 on adipogenesis and the relevant molec...
Source: IUBMB Life - Category: Research Authors: Tags: RESEARCH COMMUNICATION Source Type: research
AbstractBackgroundOne-anastomosis gastric bypass/mini-gastric bypass (OAGB/MGB) remains controversial because it may cause chronic biliary reflux (BR). The risk of developing esogastric cancer due to BR after OAGB/MGB is based on the results of experimental rat studies using esojejunostomy (EJ). The aim of this study was to analyze the potential long-term consequences of BR on the esogastric mucosae in OAGB/MGB-operated rats and to compare these results to those from the use of EJ.MethodsWistar rats received OAGB/MGB (n = 16), EJ (n = 16), and sham (n = 8) operations. Mortality and...
Source: Obesity Surgery - Category: Surgery Source Type: research
;llertz A Abstract The release and absorption profile of an oral medication is influenced by the physicochemical properties of the drug and its formulation, as well as by the anatomy and physiology of the gastrointestinal (GI) tract. During drug development the bioavailability of a new drug is typically assessed in early clinical studies in a healthy adult population. However, many disease conditions are associated with an alteration of the anatomy and/or physiology of the GI tract. The same holds true for some subpopulations, such as paediatric or elderly patients, or populations with different ethnicity. The var...
Source: European Journal of Pharmaceutical Sciences - Category: Drugs & Pharmacology Authors: Tags: Eur J Pharm Sci Source Type: research
CONCLUSIONS: Our robotic approach using an oval-shaped port device for gastric cancer patients is feasible in terms of patient safety and curability. PMID: 32077483 [PubMed - as supplied by publisher]
Source: Surgical Technology International - Category: Surgery Tags: Surg Technol Int Source Type: research
Publication date: April 2020Source: Cancer Epidemiology, Volume 65Author(s): Su Zhang, Jian-Bing Wang, Huan Yang, Jin-Hu Fan, You-Lin Qiao, Philip R. TaylorAbstractBackgroundAlthough a number of previous studies have noted the association between body mass index (BMI) and upper gastrointestinal (UGI) cancer risk, little evidence exists in the Chinese esophageal squamous dysplasia population. This prospective study investigated the association between BMI and UGI cancer risk in the Linxian Dysplasia Nutrition Intervention Trial (NIT) cohort.MethodsA total of 3298 participants were included in the final analysis. Asian-speci...
Source: Cancer Epidemiology - Category: Cancer & Oncology Source Type: research
The landscape of gastroesophageal reflux disease (GERD) management is changing, in a good way. Several key forces have converged (Box  1), propelling us to see GERD with a new perspective. One of these forces is the expanding role of the interventional gastrointestinal endoscopist in foregut diseases, including GERD, Barrett’s and early esophageal cancer, achalasia, Zenker diverticulum, early gastric cancer, gastric outlet obst ruction, and obesity. Accordingly, when tapped by Dr Lightdale to be the editor of this issue devoted to GERD management, I had the privilege of assembling some of the top GERD authoritie...
Source: Gastrointestinal Endoscopy Clinics of North America - Category: Gastroenterology Authors: Tags: Preface Source Type: research
Endoscopy DOI: 10.1055/a-1104-5245In Europe at present, but also in 2040, 1 in 3 cancer-related deaths are expected to be caused by digestive cancers. Endoscopic technologies enable diagnosis, with relatively low invasiveness, of precancerous conditions and early cancers, thereby improving patient survival. Overall, endoscopy capacity must be adjusted to facilitate both effective screening programs and rigorous control of the quality assurance and surveillance systems required. 1 For average-risk populations, ESGE recommends the implementation of organized population-based screening programs for colorectal cancer, based...
Source: Endoscopy - Category: Gastroenterology Authors: Tags: Position Statement Source Type: research
AbstractPurposeOne anastomosis gastric bypass (OAGB) is a promising bariatric procedure. We performed this study to evaluate the changes in a group of inflammatory cytokines 12  months after OAGB.MethodsA single-arm prospective study was conducted on obese patients who underwent OAGB. The serum levels of the following adipocytokines were monitored pre- and 12  months postoperatively: adiponectin, leptin, interleukin 6 (IL-6), interleukin 8 (IL-8) levels, tumor necrosis factor-alpha (TNF-α), serum amyloid A (SAA), high-sensitivity C-reactive protein (hs-CRP), and monocyte chemotactic protein 1 (MCP-1).Result...
Source: Obesity Surgery - Category: Surgery Source Type: research
This study examined perioperative and oncologic results of gastrectomy in obese patients diagnosed with gastric cancer. BMI ≥30 kg/m² was used to designate obesity. Five hundred and one patients were operated throughout the study period (2009-2018). The outcomes in obese patients (n = 205) were compared with those with normal weight (n = 171) and overweight (n = 125). The mean BMI was significantly different between the groups: 21.9 versus 26.7 versus 33.3 kg/m² (P
Source: The American Surgeon - Category: Surgery Authors: Tags: Am Surg Source Type: research
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