Urate and Osteoarthritis: Evidence For a Reciprocal Relationship

Publication date: Available online 22 November 2018Source: Joint Bone SpineAuthor(s): Tuhina Neogi, Svetlana Krasnokutsky, Michael H. PillingerAbstractHyperuricemia is a common condition, and in a subset of patients leads to gout, the most common inflammatory arthritis. Osteoarthritis is the most common form of arthritis overall, and gout and osteoarthritis frequently coexist in the same patient. However, the relationship between the two remains poorly defined. More particularly, the impact of osteoarthritis on the development of gout, and the impact of gout on the development of osteoarthritis, remain to be determined. Additionally, whether hyperuricemia mediates osteoarthritis in the absence of gout is uncertain. Here, we review the evidence linking gout and osteoarthritis, with a special focus on the role of hyperuricemia in the presence or absence of gout. Since disease modifying agents are currently available for hyperuricemia and gout but not for osteoarthritis, a contributory role for urate in the pathogenesis of osteoarthritis could have important clinical implications.
Source: Joint Bone Spine - Category: Orthopaedics Source Type: research

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This study aims to discuss plasma and messenger RNA (mRNA) levels of interleukin (IL) ‐37 in rheumatoid arthritis (RA) patients and evaluate the potential of plasma IL‐37 as a biomarker for RA.MethodPlasma IL ‐37 levels and IL‐37 mRNA relative concentrations were measured by enzyme‐linked immunosorbent assay (ELISA) and quantitative reverse transcriptase‐polymerase chain reaction (RT‐PCR). We discussed the association of IL‐37 levels and clinical, laboratory parameters in RA patients in a tra ining cohort. Plasma IL‐37 levels were tested for discriminatory capacity by receiver operating characteristic (RO...
Source: International Journal of Rheumatic Diseases - Category: Rheumatology Authors: Tags: ORIGINAL ARTICLE Source Type: research
Conditions:   Rheumatoid Arthritis;   Ankylosing Spondylitis;   Fibromyalgia;   Gout;   Crohn Disease;   Juvenile Idiopathic Arthritis;   Lupus Erythematosus;   Myositis;   Osteoarthritis;   Osteoporosis;   Psoriasis;   Psoriatic Arthritis;   Scleroderma Intervention:   Sponsors:   Global Healthy Living Foundation;   University of Alabama at Birmingham Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Authors: Harth M, Nielson WR Abstract INTRODUCTION: Most arthritides are associated with pain and psychological distress (clinically significant depression and anxiety). Pain and depression are mutually exacerbating; both may continue even when joint involvement appears well controlled. Area covered: There is strong evidence that arthritis-related stress impacts the central nervous system and, together with peripheral inflammatory changes, can cause central sensitization that can lead to chronic pain and worsening of affective distress. Cytokines and chemokines participate both in joint inflammation and in central ...
Source: Expert Review of Clinical Immunology - Category: Allergy & Immunology Tags: Expert Rev Clin Immunol Source Type: research
You're reading Natural Remedies That Help Relieve Your Joint Pain, originally posted on Pick the Brain | Motivation and Self Improvement. If you're enjoying this, please visit our site for more inspirational articles. If you are among millions of people suffering from joint pain and arthritis and living on pain-killers for quite a while, there is good news for you-you can have natural remedies to get rid of your pain. Whether you are facing stiffness, reduced the range of movements, and difficulty walking, there are certain natural therapies that are pretty much safer alternatives to taking drugs. According to the Centre ...
Source: PickTheBrain | Motivation and Self Improvement - Category: Consumer Health News Authors: Tags: health and fitness Joint pain natural remedies Source Type: blogs
You're reading Natural Remedies That Help Relieve Your Joint Pain?, originally posted on Pick the Brain | Motivation and Self Improvement. If you're enjoying this, please visit our site for more inspirational articles. If you are among millions of people suffering from joint pain and arthritis and living on pain-killers for quite a while, there is good news for you-you can have natural remedies to get rid of your pain. Whether you are facing stiffness, reduced the range of movements, and difficulty walking, there are certain natural therapies that are pretty much safer alternatives to taking drugs. According to the Centre...
Source: PickTheBrain | Motivation and Self Improvement - Category: Consumer Health News Authors: Tags: health and fitness Joint pain natural remedies Source Type: blogs
You're reading What Are The Best Natural Remedies That Help Relieve Your Joint Pain?, originally posted on Pick the Brain | Motivation and Self Improvement. If you're enjoying this, please visit our site for more inspirational articles. If you are among millions of people suffering from joint pain and arthritis and living on pain-killers for quite a while, there is good news for you-you can have natural remedies to get rid of your pain. Whether you are facing stiffness, reduced the range of movements, and difficulty walking, there are certain natural therapies that are pretty much safer alternatives to taking drugs. Accor...
Source: PickTheBrain | Motivation and Self Improvement - Category: Consumer Health News Authors: Tags: health and fitness Joint pain natural remedies Source Type: blogs
ConclusionThese findings suggest that resveratrol ameliorates gouty inflammation via upregulation of SIRT1 to promote autophagy in patients with gout.
Source: Inflammopharmacology - Category: Drugs & Pharmacology Source Type: research
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Source: Reumatologia Clinica - Category: Rheumatology Source Type: research
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