Urate and Osteoarthritis: Evidence For a Reciprocal Relationship

Publication date: Available online 22 November 2018Source: Joint Bone SpineAuthor(s): Tuhina Neogi, Svetlana Krasnokutsky, Michael H. PillingerAbstractHyperuricemia is a common condition, and in a subset of patients leads to gout, the most common inflammatory arthritis. Osteoarthritis is the most common form of arthritis overall, and gout and osteoarthritis frequently coexist in the same patient. However, the relationship between the two remains poorly defined. More particularly, the impact of osteoarthritis on the development of gout, and the impact of gout on the development of osteoarthritis, remain to be determined. Additionally, whether hyperuricemia mediates osteoarthritis in the absence of gout is uncertain. Here, we review the evidence linking gout and osteoarthritis, with a special focus on the role of hyperuricemia in the presence or absence of gout. Since disease modifying agents are currently available for hyperuricemia and gout but not for osteoarthritis, a contributory role for urate in the pathogenesis of osteoarthritis could have important clinical implications.
Source: Joint Bone Spine - Category: Orthopaedics Source Type: research