Body mass index trajectories during adult life and lung function decline

Body mass index (BMI) has been associated with lung function. Whether distinct BMI trajectories during adult life affect lung function differently is unknown. We assessed associations of BMI trajectories from 34 to 54 years with lung function decline over the same period of time in the ECRHS cohort.BMI trajectories were developed using Group-Based Trajectory Modeling on data collected at least twice between ECRHS I and ECRHS III (n=9327). Associations of these trajectories with lung function decline were assessed using mixed linear regression models (adjusted for sex, age, age2, height, smoking status and baseline lung function) in a subgroup (n=3534) with lung function data at ECRHS I and III. As sex-specific analyses showed similar findings, males and females were combined.Four parallel trajectories were identified: ‘normal’, ‘overweight’, ‘obese’ and ‘morbidly obese’ (Fig. 1). Those with higher BMI trajectories had greater decline of FEV1 and FVC than those with ‘normal BMI’ trajectory (Fig. 2).Overweight and obese trajectories of BMI during adult life were associated with greater lung function decline in the ECRHS cohort.Funding: EU H2020 grant#633212

Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Peralta, G. P., Fuertes, E., Carsin, A.-E., Probst-Hensch, N., Marcon, A., Nowak, D., Amaral, A. F. S., Johannessen, A., Janson, C., Dharmage, S., Gislason, T., Garcia-Larsen, V., Abramson, M. J., Sigsgaard, T., Anto, J. M., Weyler, J., Bono, R., Holm, M. Tags: Epidemiology Source Type: research