Inflammatory mediators in eosinophilic COPD phenotype and asthma with fixed airflow obstruction

Background: Eosinophils and neutrophils play roles in asthma and COPD severity and treatment response. Cellular mediators are promising treatment targets. However, their roles in asthma and COPD phenotypes have never been investigated.Objective: To investigate eosinophilic and neutrophilic mediators in asthma with and without fixed airflow obstruction (FAO) and COPD with and without blood eosinophilia (BE).Materials and methods: Asthma, COPD patients and healthy subjects were recruited from 2016 to 2017. Spirometry and reversibility test were performed. ACT, modified MRC and CAT were assessed. Blood eosinophils, neutrophils and serum total IgE were measured. Serum IL-5, CXCL-8 and IL-17 were measured using ELISA.Results: Total 100 participants were classified to 5 groups; asthma without FAO, asthma with FAO (post-BD FEV1/FVC
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Allergy and immunology Source Type: research

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AbstractBackgroundPrevious studies have suggested an increased risk of asthma related to indoor dampness problems, but their role in the etiology of Asthma-COPD Overlap Syndrome has not been studied. We utilized a population-based incident case –control study to assess potential effect of indoor dampness and molds at home and at work on development of ACOS.MethodsWe recruited systematically all new cases of asthma diagnosed during a 2.5-year study period (1997 –2000) and randomly selected controls from the source population of adults 21–63 years old and representing 500,000 persons-years in the Pirka...
Source: Clinical and Translational Allergy - Category: Allergy & Immunology Source Type: research
Conclusions: There was increased burden of respiratory problems and lower lung volumes and flows among traffic policemen.
Source: Indian Journal of Community Medicine - Category: International Medicine & Public Health Authors: Source Type: research
Aim: Examination of patients (pts) with two broncho-obstructive diseases (A and COPD) requires addressing the issue: is it originally A or COPD? We looked at the problem from COPD.Material and Methods: We studied 38 smokers with COPD II-III stages (age–61.4±3.8 yrs, pack/year–28.8±4.3) repeatedly (3-8 yrs) in stable phase on adequate therapy. Measurements included clinical status, spirometry with bronchoobstructive reversibility test (BORT) and allergic markers: blood eosinophil level (E), common IgE level (cIgE) in plasma, Phadiatop (Ph) in serum. Each patient underwent from 3 to 9 (6.2±1....
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Allergy and immunology Source Type: research
Conclusions: The COPD patients included in this study had no specific clinical characteristics, depending on blood eosinophil count. Further larger prospective studies are needed.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Allergy and immunology Source Type: research
Conclusion: COPD patients with comorbid asthma had higher risk of exacerbations. Lower lung function and IgE-sensitization were associated to exacerbations in the one-year follow-up.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: General practice and primary care Source Type: research
Mario Malerba1,2*, Valentina Foci1,2, Filippo Patrucco1,2, Patrizia Pochetti1,2, Matteo Nardin3, Corrado Pelaia4 and Alessandro Radaeli5 1Respiratory Medicine, Department of Translational Medicine, University of Eastern Piedmont, Vercelli, Italy 2Respiratory Unit, Sant’Andrea Hospital, Vercelli, Italy 3Department of Medicine, Spedali Civili di Brescia, Brescia, Italy 4Department of Medical and Surgical Sciences, Section of Respiratory Diseases, University “Magna Græcia” of Catanzaro, Catanzaro, Italy 5Department of Emergency, Spedali Civili di Brescia, Brescia, Italy Chronic obstructiv...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
CONCLUSIONS: TGlittre-P reference equations were developed for females and males, with age being the most influential predictive variable in the test performed by children. PMID: 30992402 [PubMed - as supplied by publisher]
Source: Respiratory Care - Category: Respiratory Medicine Authors: Tags: Respir Care Source Type: research
ConclusionWhile most PCPs and respiratory/allergy specialists can reach a working diagnosis of ACO, there remains uncertainty around which diagnostic features are most important and what constitutes optimal management. It is imperative that clinical studies including patients with ACO are initiated, allowing the generation of evidence ‐based management strategies.This article is protected by copyright. All rights reserved.
Source: The Clinical Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Original Article Source Type: research
Forced oscillation technique (FOT) has a potential to evaluate respiratory pathophysiology in asthma that spirometry does not detect. Since lung function decline in children with asthma has been reported to have significant impact on development of COPD in later life, we investigated changes in FOT parameters in children/adolescents with asthma in relation with changes in maximal expiratory flow at 50 % of the forced vital capacity (MEF50), an index for the small airways.
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Source Type: research
Conclusions: The present results provide new insight into the role of allergy and heredity for ACOS among subjects with adult-onset asthma. Prevention of smoking and facilitating stopping smoking are important among asthmatic subjects to prevent development of the COPD component.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Epidemiology Source Type: research
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