Effect of Dapagliflozin in T2D Patients With Stages 3b-4 CKD Effect of Dapagliflozin in T2D Patients With Stages 3b-4 CKD

Is dapagliflozin an effective therapeutic option for patients with type 2 diabetes and chronic kidney disease? How does it impact clinical outcomes in these patients?Nephrology Dialysis Transplantation
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Nephrology Journal Article Source Type: news

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This study aims to specify the epidemio-logical, clinical, and biological characteristics of diabetic disease, chronic kidney disease (CKD), and comorbidities at the initiation of HD and investigate factors associated with mortality during the dialysis period. We retrospectively analyzed the outcome of diabetic patients who were initiated on HD from 2007 to 2012 at the Rabta Hospital of Tunis. During the follow-up period, all morbid events and deaths were recorded. Univariate analysis and multivariate analysis were performed to identify risk factors associated with mortality in our population. The study population included...
Source: Saudi Journal of Kidney Diseases and Transplantation - Category: Urology & Nephrology Authors: Tags: Saudi J Kidney Dis Transpl Source Type: research
AbstractPurpose of ReviewTrimethylamine N-oxide (TMAO) is a gut microbiota-dependent metabolite produced from choline and phosphatidylcholine. Trimethylamine N-oxide was found associated with enhanced atherosclerosis and thrombosis in vitro and in vivo. We summarized available clinical studies which investigated TMAO ’s role in predicting prognostic outcomes, including mortality, in patients with cardiovascular diseases.Recent FindingsIn chronic kidney disease cohorts, higher TMAO levels were significantly associated with higher mortality from 1.18 to 4.32 folds. Higher TMAO levels were not significantly associated w...
Source: Current Nutrition Reports - Category: Nutrition Source Type: research
Our patient is a 60-year-old female with a past medical history significant for diabetes mellitus type 2, smoking, anal cancer status-post transrectal excision with no evidence of recurrence or metastasis, rheumatoid arthritis, systemic lupus erythematosus and end-stage renal disease (ESRD) on hemodialysis (HD). She had progressive chronic kidney disease for approximately 25 years, ultimately starting HD 3 years prior to this evaluation. She presented to the urology department for evaluation prior to kidney transplantation.
Source: Urology - Category: Urology & Nephrology Authors: Source Type: research
There is a large and growing burden of diabetes globally. In 2013, 382 million people had diabetes and this number has been projected to increase to 592 million by 2035 [1]. With increasing life expectancy and prevalence of type 2 diabetes, complications and deaths attributable to diabetes will also increase, especially if there is no concomitant improvement in the health system for its early management [1]. Chronic kidney disease (CKD) is a common complication in people with type 2 diabetes [2] and may in some cases progress to end-stage renal disease, which requires dialysis and/or kidney transplant which are associated ...
Source: Primary Care Diabetes - Category: Primary Care Authors: Tags: Original research Source Type: research
Conclusions: Bardoxolone methyl preserves kidney function and may delay the onset of ESRD in patients with T2D and stage 4 CKD.Am J Nephrol 2018;47:40 –47
Source: American Journal of Nephrology - Category: Neurology Source Type: research
In this study, we have shown that the lipid chaperones FABP4/FABP5 are critical intermediate factors in the deterioration of metabolic systems during aging. Consistent with their roles in chronic inflammation and insulin resistance in young prediabetic mice, we found that FABPs promote the deterioration of glucose homeostasis; metabolic tissue pathologies, particularly in white and brown adipose tissue and liver; and local and systemic inflammation associated with aging. A systematic approach, including lipidomics and pathway-focused transcript analysis, revealed that calorie restriction (CR) and Fabp4/5 deficiency result ...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Metabolic surgery offers the opportunity to durably address several obesity-related co-morbidities, many of which have complex interaction and deleterious end-organ effects [1]. The destructive potential of type 2 diabetes, for instance, on renal function in morbidly obese patients is well known and need not be summarized for this audience. Patients with impaired renal function are common in bariatric practices/programs and may present anywhere along the chronic kidney disease spectrum, even including dialysis-dependent patients seeking bariatric surgery as a potential bridge to renal transplant [2].
Source: Surgery for Obesity and Related Diseases - Category: Surgery Authors: Tags: Editorial comment Source Type: research
Conclusions Most ESRD cases occurred in individuals without intercurrent CV events who had lower eGFRs than individuals with intercurrent CV events, but similar post-ESRD mortality. Nevertheless, intercurrent CV events, particularly heart failure, are strongly associated with risk for ESRD. These findings underscore the need for kidney-specific therapies in addition to treatment of CV risk factors to lower ESRD incidence in diabetes.
Source: American Journal of Kidney Diseases - Category: Urology & Nephrology Source Type: research
Background Diabetic kidney disease is the leading cause of stage 5 chronic kidney disease (CKD) in India. Renal replacement therapy (RRT) is accessible to very few patients because of socioeconomic deprivation. We studied the effect of diabetes and socioeconomic status on the outcome of patients on maintenance hemodialysis (MHD). Methods We retrospectively analyzed the outcome of 897 patients (629 males/268 females; mean age ± standard deviation 48.69 ± 14.27 years) initiated on MHD from 2003 to 2009 at five dialysis centers in south India. There were 335 type 2 diabetic patients and 562 non-diabetic patient...
Source: CKJ: Clinical Kidney Journal - Category: Urology & Nephrology Authors: Tags: HAEMODIALYSIS Source Type: research
Conclusions High Lp(a) concentrations and LMW apo(a) isoforms are risk predictors for all-cause mortality and death due to infection in haemodialysis patients with diabetes mellitus. These associations are modified by age.
Source: Nephrology Dialysis Transplantation - Category: Urology & Nephrology Authors: Tags: Chronic Kidney Disease Source Type: research
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