Retrospective evaluation of children with immune thrombocytopenic purpura and factors contributing to chronicity

Immune thrombocytopenic purpura (ITP) is the most common cause of acquired thrombocytopenia children. The aim of this retrospective study is to describe presenting features and clinical characteristics of ITP and evaluate clinical course, treatment modalities, and complications and determine the effects of preceding infection history, age, gender, treatment modality, and admission platelet count on chronicity.
Source: Pediatrics and Neonatology - Category: Perinatology & Neonatology Authors: Tags: Original Article Source Type: research

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Conclusions: Severe malaria is a highly frequent event in pregnant women, without differences by Plasmodium species. It shows early recognizable dangers signs. Hospital under-reporting was identified in 88% of severe cases as well as a lack of laboratory tests for a more comprehensive diagnosis. A protocol for the clinical diagnosis of pregnant women with malaria is required. PMID: 31529822 [PubMed - in process]
Source: Biomedica : Revista del Instituto Nacional de Salud - Category: International Medicine & Public Health Tags: Biomedica Source Type: research
In conclusion, the -201 G/A polymorphism of IP-10 gene may be associated with the susceptibility of ITP in Chinese population. PMID: 31530029 [PubMed - as supplied by publisher]
Source: Autoimmunity - Category: Allergy & Immunology Tags: Autoimmunity Source Type: research
Conclusion: This case demonstrates the importance of a broad differential diagnosis for a child presenting with leg pain and fever. PMID: 31528139 [PubMed]
Source: Ochsner Journal - Category: General Medicine Tags: Ochsner J Source Type: research
The term thrombotic microangiopathy (TMA) refers to a syndrome consisting of  microangiopathic hemolytic anemia, thrombocytopenia, and organ dysfunction with normal coagulation parameters.1 The designations “primary” and “secondary” to TMA are arbitrary and reflect underlying mechanisms. The primary TMA syndromes include thrombotic thrombocytopenic purpura related t o a deficiency of the von Willebrand factor protease ADAMTS13, diarrhea-associated hemolytic uremic syndrome associated with infection with Shiga toxin producing enteric organisms, and complement-mediated TMA or atypical hemolytic u...
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Controversies in Nephrology Source Type: research
Condition:   Immune Thrombocytopenia Interventions:   Drug: Rocaltrol;   Drug: Dexamethasone Sponsor:   Shandong University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Publication date: Available online 18 September 2019Source: Clinical Lymphoma Myeloma and LeukemiaAuthor(s): Eman O. Rasekh, Ghada M. Elsayed, Youssef Madney, Mosaad M. El GammalAbstractBackgroundAcute promyelocytic leukemia (APL) has a characteristic peculiar morphologic, genetic features and more favorable outcome.Objective; was to study the differential effect of bcr-1 and bcr-3 isoforms of PML-RARA transcript together with FMS like tyrosine kinase-3 internal tandem duplication (FLT3-ITD) mutational status on outcome of newly diagnosed de novo APL patients.Patients and methodsThis cohort study included all patients diag...
Source: Clinical Lymphoma Myeloma and Leukemia - Category: Cancer & Oncology Source Type: research
This study assesses the clinical effect of SFI combined with chemotherapy for breast cancer patients. Materials and methods: Both English and Chinese databases were searched covering the time period of 1999- 2018 for relevant studies comparing the effect of SFI plus chemotherapy treatment with chemotherapy alone in patients with breast cancer. Target outcomes concerning treatment effect, performance status, immune system and toxic effects were extracted and combined using Stata version 15.0 software. Quality assessment was performed using the Jadad scale. Results: Forty-nine trials were included based on certain selection ...
Source: Pharmaceutical Biology - Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research
CONCLUSION This precision medicine approach identifies PI3K/Akt/mTOR signaling as the first pharmacologically targetable pathogenic process in IL-6 blockade–refractory iMCD. Prospective evaluation of sirolimus in treatment-refractory iMCD is planned (NCT03933904).FUNDING This study was supported by the Castleman’s Awareness &Research Effort/Castleman Disease Collaborative Network, Penn Center for Precision Medicine, University Research Foundation, Intramural NIH funding, and the National Heart Lung and Blood Institute.
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
AbstractLusutrombopag (Mulpleta®), an orally bioavailable, small molecule thrombopoietin receptor agonist, is approved for the treatment of thrombocytopenia in adult patients with chronic liver disease who are scheduled to undergo a procedure. In placebo-controlled phase  3 clinical trials, lusutrombopag significantly increased the proportion of patients who did not require a platelet transfusion prior to the procedure or rescue therapy for bleeding up to 7 days after the scheduled procedure. Lusutrombopag also significantly increased the proportion of patients wh o were responders (i.e. had a platelet count&...
Source: Drugs - Category: Drugs & Pharmacology Source Type: research
Authors: Fogagnolo A, Taccone FS, Campo G, Montanari G, Capatti B, Ferraro G, Erriquez A, Ragazzi R, Creteur J, Volta CA, Spadaro S Abstract Coagulation disorders and thrombocytopenia are common in patients with septic shock, but only few studies have focused on platelet variables beyond platelet count. The aim of this study was to evaluate whether platelets reactivity predicts sepsis-induced thrombocytopenia in patients with septic shock. We therefore enrolled consecutive patients with septic shock and platelets count>150*103/μL on the day of the diagnosis. Platelets reactivity tests were performed daily fro...
Source: Platelets - Category: Hematology Tags: Platelets Source Type: research
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