GSE105148 A metabolic checkpoint controls hyphal development in Candida albicans via nitric oxide signaling

Contributors : Ana Traven ; Paul F Harrrison ; Traude H BeilharzSeries Type : Expression profiling by high throughput sequencingOrganism : Candida albicansWe investigated the roles of mitochondrial dynamics in hyphal growth of C. albicans using the small molecule inhibitor MDIVI-1. Strikingly, the small molecule inhibitor represses both the yeast-to hyphae transition and ongoing filamentation, and its effects on morphogenesis can be uncoupled from general growth inhibition. RNAseq experiments of inhibitor-treated cells coupled with Candida mutant analyses suggest the existence of a novel mechanism of action to represses hyphal growth. The inhibitor was protective to host cells, increasing the survival of bone-marrow derived macrophages in ex vivo macrophage-Candida infection assays, suggesting it has potential as a therapeutic.

Source: GEO: Gene Expression Omnibus - November 20, 2018 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Candida albicans Source Type: research