MicroRNA Regulation of Energy Metabolism to Induce Chemoresistance in Cancers.

MicroRNA Regulation of Energy Metabolism to Induce Chemoresistance in Cancers.
Technol Cancer Res Treat. 2018 Jan 01;17:1533033818805997
Authors: Ye J, Zou M, Li P, Liu H
Abstract
Since "Warburg effect" has been firstly uncovered in cancer cells in 1956, mounting evidence has supported the molecular mechanism underlying the energy metabolism in induced chemoresistance in cancers. MicroRNAs can mediate fine-tuning of genes in physiological process. MicroRNAs' energy metabolic role in chemoresistance has been probed recently. In this review, we summarize 5 microRNAs in regulating glucose and lipid metabolism and other energy metabolism. They partially modulate chemoresistance to cancer treatments. Furthermore, we discuss the great therapeutic potential of metabolism-related microRNAs in novel combinatorial means to treat human cancers.
PMID: 30444190 [PubMed - in process]

Source: Technology in Cancer Research and Treatment - January 1, 2018 Category: Cancer & Oncology Authors: Ye J, Zou M, Li P, Liu H Tags: Technol Cancer Res Treat Source Type: research