Plasma extracellular nanovesicle (exosome) ‐derived biomarkers for drug metabolism pathways: a novel approach to characterize variability in drug exposure

ConclusionsConsistent strong concordance was observed between exosome ‐derived CYP3A4 biomarkers and midazolam CL/F. The significance of these results is that CYP3A4 is the drug‐metabolizing enzyme of greatest clinical importance and variability in CYP3A4 activity is poorly described by existing precision dosing strategies.

Source: British Journal of Clinical Pharmacology - November 16, 2018 Category: Drugs & Pharmacology Authors: Andrew Rowland, Warit Ruanglertboon, Madel é Dyk, Dhilushi Wijayakumara, Linda S. Wood, Robyn Meech, Peter I. Mackenzie, A. David Rodrigues, Jean‐Claude Marshall, Michael J. Sorich Tags: ORIGINAL ARTICLE Source Type: research