The hippo pathway effector Yes ‐associated protein promotes epithelial proliferation and remodeling in chronic rhinosinusitis with nasal polyps

ConclusionsHippo pathway components are abnormally upregulated in NPECs, and its effector YAP promotes nasal epithelial cells proliferation and remodeling in CRSwNP. It provides a rationale to explore inhibition of YAP as a novel therapeutic strategy for reducing the epithelial proliferation and remodeling in CRSwNP.

Source: Allergy - November 18, 2018 Category: Allergy & Immunology Authors: Huiyi Deng, Yueqi Sun, Weihao Wang, Meijiao Li, Tian Yuan, Weifeng Kong, Xuekun Huang, Zijie Long, Zhuanggui Chen, Deyun Wang, Qintai Yang Tags: ORIGINAL ARTICLE Source Type: research