Developmental and functional characteristics of the thoracic aorta perivascular adipocyte.

Developmental and functional characteristics of the thoracic aorta perivascular adipocyte.
Cell Mol Life Sci. 2018 Nov 17;:
Authors: Ye M, Ruan CC, Fu M, Xu L, Chen D, Zhu M, Zhu D, Gao P
Abstract
Thoracic aorta perivascular adipose tissue (T-PVAT) has critical roles in regulating vascular homeostasis. However, the developmental characteristics and cellular lineage of adipocyte in the T-PVAT remain unclear. We show that T-PVAT contains three long strip-shaped fat depots, anterior T-PVAT (A-T-PVAT), left lateral T-PVAT (LL-T-PVAT), and right lateral T-PVAT (RL-T-PVAT). A-T-PVAT displays a distinct transcriptional profile and developmental origin compared to the two lateral T-PVATs (L-T-PVAT). Lineage tracing studies indicate that A-T-PVAT adipocytes are primarily derived from SM22α+ progenitors, whereas L-T-PVAT contains both SM22α+ and Myf5+ cells. We also show that L-T-PVAT contains more UCP1+ brown adipocytes than A-T-PVAT, and L-T-PVAT exerts a greater relaxing effect on aorta than A-T-PVAT. Angiotensin II-infused hypertensive mice display greater macrophage infiltration into A-T-PVAT than L-T-PVAT. These combined results indicate that L-T-PVAT has a distinct development from A-T-PVAT with different cellular lineage, and suggest that L-T-PVAT and A-T-PVAT have different physiological and pathological functions.
PMID: 30448891 [PubMed - as supplied by publisher]

Source: Cellular and Molecular Life Sciences : CMLS - November 17, 2018 Category: Cytology Authors: Ye M, Ruan CC, Fu M, Xu L, Chen D, Zhu M, Zhu D, Gao P Tags: Cell Mol Life Sci Source Type: research